al-Waiz M, Mitchell S C
Department of Pharmacology and Toxicology, St. Mary's Hospital Medical School, Paddington, London, England.
Drug Metabol Drug Interact. 1991;9(1):41-8. doi: 10.1515/dmdi.1991.9.1.41.
The metabolism and excretion of [14C]-trimethylamine has been investigated in seven strains of rat. Over 75% of the administered radioactivity was excreted via the urine within the first day, with up to 9% in the faeces. At this dose level (15 mg/kg body wt) N-oxidation was the major metabolic pathway encountered (45% excreted dose) whilst demethylation was only of minor importance (3%). The remaining compound was excreted unchanged. No significant differences were observed between the strains studied.
