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用于药物剂量调整的估计肾小球滤过率：Cockcroft和Gault公式还是简化的MDRD公式？

Estimated glomerular filtration rate for drug dose adjustment: Cockcroft and Gault or abbreviated MDRD equation?

作者信息

Roblin Isabelle, De Sobarnitsky Sophie, Basselin Cécile, Vial Fabienne, Bard Emmanuel, Dufrene Isabelle, Hida Hassan, Laurencin Christian

机构信息

Pharmacy Department, Valence Hospital, 26000 Valence, France.

出版信息

Clin Biochem. 2009 Jan;42(1-2):111-3. doi: 10.1016/j.clinbiochem.2008.09.110. Epub 2008 Oct 9.

DOI:10.1016/j.clinbiochem.2008.09.110
PMID:18938149
Abstract

OBJECTIVES

Evaluate if Cockcroft and Gault (CG) estimated glomerular filtration rate (eGFR) might be replaced by abbreviated MDRD eGFR for drug dose adjustment.

DESIGN AND METHODS

eGFR was determined in 140 hospitalized patients (median: 68 years, 65 kg) treated by nephrotoxic and/or renally cleared drugs.

RESULTS

CG eGFR was 61 mL/min vs. 78 mL/min/1.73 m(2) for MDRD (p<0.0001). CG-MDRD difference ranged from -93 to +34 mL/min, influenced by patient age, weight, and gender (p<0.001).

CONCLUSIONS

CG eGFR cannot be easily replaced by abbreviated MDRD eGFR for drug dose adjustment.

摘要

目的

评估对于药物剂量调整，是否可用简化的肾脏病饮食改良试验（MDRD）估算肾小球滤过率（eGFR）取代考克饶夫特-高尔特（CG）公式估算的肾小球滤过率。

设计与方法

对140例接受肾毒性和/或经肾清除药物治疗的住院患者（中位数：68岁，65千克）测定eGFR。

结果

CG公式估算的eGFR为61毫升/分钟，而MDRD公式估算的为78毫升/分钟/1.73平方米（p<0.0001）。CG与MDRD公式估算值的差异范围为-93至+34毫升/分钟，受患者年龄、体重和性别影响（p<0.001）。

结论

对于药物剂量调整，CG公式估算的eGFR不能轻易被简化的MDRD公式估算的eGFR所取代。

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