Olatunji L A, Oyeyipo I P, Micheal O S, Soladoye A O
Department of Physiology, College of Health Sciences, University of Ilorin, P.M.B 1515, Ilorin, 240001, Nigeria.
Afr J Med Med Sci. 2008 Jun;37(2):135-9.
Studies that associated oestrogen-progestogen oral contraceptive (OC) use with altered glucose and lipid metabolisms in women did not account for possible influence in dietary magnesium. The use of OC and glucose and lipid metabolism seems to remain a broad public health concern since over 100 million women use OC world wide for a prolonged period of time. The study, therefore, sought to investigate in a female rat model whether or not glucose intolerance and dyslipidaemia associated with OC are influenced by dietary magnesium status. Control and OC- treated rats were maintained on control diet, whereas OC+ Mg- treated rats were on high magnesium diet. OC- treated and OC+Mg treated rats also received a combination of OC steroids, ethinyl oestradiol and norgestrel (orally). When compared with the controls, OC treatment led to significant reduced glucose tolerance and plasma HDL-cholesterol and significant increases in plasma LDL-cholesterol and atherogenic indices in OC- treated rats. Treatment with OC did not result in significant attenuation in these parameters in OC+Mg- treated rats when compared with the controls. In conclusion, these results suggest that impaired glucose tolerance and dyslipidaemia associated with OC use may be prevented by increased dietary magnesium.
将雌激素 - 孕激素口服避孕药（OC）的使用与女性葡萄糖和脂质代谢改变相关联的研究未考虑到饮食中镁的可能影响。由于全球有超过1亿女性长期使用OC，OC的使用与葡萄糖和脂质代谢问题似乎仍然是一个广泛的公共卫生关注点。因此，该研究试图在雌性大鼠模型中调查与OC相关的葡萄糖不耐受和血脂异常是否受饮食镁状态的影响。对照大鼠和接受OC治疗的大鼠维持正常饮食，而接受OC + Mg治疗的大鼠则给予高镁饮食。接受OC治疗和OC + Mg治疗的大鼠也口服了OC类固醇、炔雌醇和炔诺孕酮的组合。与对照组相比，OC治疗导致接受OC治疗的大鼠葡萄糖耐量显著降低、血浆高密度脂蛋白胆固醇显著降低，而血浆低密度脂蛋白胆固醇和致动脉粥样硬化指数显著升高。与对照组相比，OC + Mg治疗的大鼠接受OC治疗后这些参数没有显著变化。总之，这些结果表明，增加饮食中的镁含量可能预防与使用OC相关的葡萄糖耐量受损和血脂异常。
