Balogun W O, Adeleye J O, Akinlade K S, Adedapo K S, Kuti M
Department of Medicine, University of Ibadan, University College Hospital, Ibadan, Nigeria.
Afr J Med Med Sci. 2008 Jun;37(2):177-83.
Liver function tests (LFTs) are commonly deranged in diabetic patients. There is, however, paucity of local data on actual prevalence and pattern of LFTs abnormality among diabetic patients. A case-control study was carried out to study the pattern of LFTs abnormality among patients with type 2 diabetes (DM). Ninety consecutive patients with type 2 diabetes attending Medical Outpatient Clinic of the University College Hospital, Ibadan, and 90 nondiabetic controls with comparable age and sex were recruited into the study. Serum albumin, alanine amino transferase (ALT) and Gamma glutamyl transpeptidase (GGT) were tested in all subjects. Data were analyzed using Student's t-test, chi-square test and Mann-Whitney U. Among the diabetic patients, 70% had at least one deranged LFTs. The ALT and GGT values were significantly higher (52.9 IU/L and 24.3 U/L respectively) in the diabetic group compared to the controls (34.4 IU/L and 9.2 U/L respectively). Also, the most predominant LFT abnormality in diabetic group was isolated elevation of GGT. This study has confirmed the reported common derangement of LFTs in patients with type 2 DM. In addition, isolated elevation of GGT and ALT are common in Nigerian type 2 diabetic patients. There is need for further study to determine the significance of high GGT and ALT in Nigerian type 2 diabetic population.
肝功能检查（LFTs）在糖尿病患者中通常会出现异常。然而，关于糖尿病患者肝功能检查异常的实际患病率和模式，当地的数据却很匮乏。开展了一项病例对照研究，以研究2型糖尿病（DM）患者肝功能检查异常的模式。连续招募了90名在伊巴丹大学学院医院门诊就诊的2型糖尿病患者，以及90名年龄和性别匹配的非糖尿病对照者进入该研究。对所有受试者进行了血清白蛋白、丙氨酸转氨酶（ALT）和γ-谷氨酰转肽酶（GGT）检测。数据采用学生t检验、卡方检验和曼-惠特尼U检验进行分析。在糖尿病患者中，70%至少有一项肝功能检查指标异常。糖尿病组的ALT和GGT值（分别为52.9 IU/L和24.3 U/L）显著高于对照组（分别为34.4 IU/L和9.2 U/L）。此外，糖尿病组最主要的肝功能异常是GGT单独升高。本研究证实了报道的2型糖尿病患者肝功能检查常见异常。此外，GGT和ALT单独升高在尼日利亚2型糖尿病患者中很常见。需要进一步研究以确定高GGT和ALT在尼日利亚2型糖尿病人群中的意义。
