Alam Sana, Raghav Alok, Reyaz Alisha, Ahsan Akif, Ahirwar Ashok Kumar, Jain Vineet, Agarwal Saurabh, Tripathi Prashant
Department of Biochemistry, Hamdard Institute of Medical Sciences and Research, New Delhi, 110062, India.
Multidisciplinary Research Unit, Department of Health Research, Ministry of Health and Family Welfare, GSVM Medical College, Kanpur, Uttar Pradesh, 208002, India.
Metabol Open. 2021 Sep 24;12:100130. doi: 10.1016/j.metop.2021.100130. eCollection 2021 Dec.
Non-alcoholic fatty liver disease (NAFLD) also referred as metabolic as metabolic (dysfunction) associated fatty liver disease. Type 2 diabetes mellitus (T2DM) is a major cause in progression of NAFLD and non-alcoholic steatohepatitis (NASH). The aim of the present study is to assess the activity of liver enzymes in T2DM in North Indian population.
This was a cross-sectional descriptive study clinic-based study in patients with T2DM. A total of 612 participants (226 healthy controls and 386 T2DM) were recruited. Body mass index (BMI), activity of liver enzymes including alanine and aspartate aminotransferase (ALT, AST) along with alkaline phosphatase (ALP) was measured. Fasting blood glucose (FBG) and glycosylated hemoglobin (HbA1c) along with total protein (TP) and albumin were also measured. Quantitative variables were expressed as mean ± SD, while qualitative variables as frequencies (%). Pearson/Spearman correlation test, unpaired -test, Chi-squared test was used to assess the correlation, association and significant differences between study groups respectively. A P-value of < .05 was set as statistically significant. The Statistical Package for Social Sciences (SPSS) ® Statistics, version 23 (IBM SPSS Statistics, Armonk, NY) was used to for analysis of data.
The study was conducted on 386 T2DM patients, and out of 386 patients, 139 (36.01%) were male (P < .000) and 247 (63.98%) were female. The mean age of the T2DM patients was 46.4 ± 13.6 years, while healthy individuals have mean age of 39.2 ± 12.0 years (P < .000). It was observed that the activity of AST in T2DM is comparable with the healthy persons (P = .060). While the level of ALT, total bilirubin and ALP in T2DM is significantly higher compared to healthy control (P < .000). On average, 62.53% of T2DM subjects and 32% of participants of healthy subjects had abnormal liver enzymes activity.
The present study has revealed widely co-existent derangements in liver function tests (LFTs) in the diabetic population of North India. A detailed workup in such patients may be helpful in timely diagnosis and treatment. Moreover, early detection and management of abnormal liver parameters in T2DM would help minimize liver-related morbidity and mortality.
非酒精性脂肪性肝病（NAFLD）也被称为代谢性（功能障碍）相关脂肪性肝病。2型糖尿病（T2DM）是NAFLD和非酒精性脂肪性肝炎（NASH）进展的主要原因。本研究的目的是评估北印度人群中T2DM患者的肝酶活性。
这是一项基于门诊的T2DM患者横断面描述性研究。共招募了612名参与者（226名健康对照者和386名T2DM患者）。测量了体重指数（BMI）、包括丙氨酸和天冬氨酸转氨酶（ALT、AST）以及碱性磷酸酶（ALP）在内的肝酶活性。还测量了空腹血糖（FBG）、糖化血红蛋白（HbA1c）以及总蛋白（TP）和白蛋白。定量变量以均值±标准差表示，而定性变量以频率（%）表示。分别使用Pearson/Spearman相关检验、非配对t检验、卡方检验来评估研究组之间的相关性、关联性和显著差异。将P值<0.05设定为具有统计学意义。使用社会科学统计软件包（SPSS）®Statistics 23版（IBM SPSS Statistics，纽约州阿蒙克）进行数据分析。
该研究对386名T2DM患者进行，在386名患者中，139名（36.01%）为男性（P<0.000），247名（63.98%）为女性。T2DM患者的平均年龄为46.4±13.6岁，而健康个体的平均年龄为39.
