Le Gac Stéphane, Ménand Mickaël, Jabin Ivan
URCOM, Université du Havre, FST, Le Havre cedex, France.
Org Lett. 2008 Nov 20;10(22):5195-8. doi: 10.1021/ol8021726. Epub 2008 Oct 22.
The efficient syntheses of calix[6]azacryptands decorated with anion-binding groups on the narrow rim have been achieved from an 1,3,5-tris-protected calix[6]hexa-amine. These heteroditopic receptors can bind ammonium ions or organic ion pair salts with a positive cooperativity. In regard to their functionalization at the 1,3,5-phenolic positions, these compounds constitute the first examples of a second generation of C3 v symmetrical calix[6]azacryptands.
已通过1,3,5-三保护杯[6]六胺实现了在窄边缘带有阴离子结合基团的杯[6]氮杂穴醚的高效合成。这些异双位点受体可以以正协同性结合铵离子或有机离子对盐。关于它们在1,3,5-酚羟基位置的功能化，这些化合物构成了第二代C3 v对称杯[6]氮杂穴醚的首个实例。
