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[绒毛膜促性腺激素对小鼠胸腺结构和内分泌功能的影响]

[Effect of chorionic gonadotropin on the structure and endocrine function of the thymus gland in mice].

作者信息

Labunets I F

出版信息

Fiziol Zh (1978). 1991 May-Jun;37(3):75-80.

PMID:1894055
Abstract

The thymic secretory function changes in the pubertal female mice under the influence of chorionic gonadotrophin (CG). The latter is activated after administration of hormone in doses, corresponding to its levels in animals in different terms of pregnancy and is depressed with doses, greatly exceeding those levels. The lack of the effect in thymectomized mice testifies to the realization of the modulating CG action at the thymus level. Changes of mass and cellularity of the thymus and spleen reflect dose-dependent alteration of the thymocyte migration rate.

摘要

在绒毛膜促性腺激素(CG)的影响下,青春期雌性小鼠的胸腺分泌功能会发生变化。给予与动物在不同孕期水平相对应剂量的激素后,后者被激活;而给予大大超过这些水平的剂量时,其活性则受到抑制。胸腺切除小鼠中缺乏这种效应,证明了CG在胸腺水平发挥调节作用。胸腺和脾脏的质量及细胞数量的变化反映了胸腺细胞迁移率的剂量依赖性改变。

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