含胸腺激素的细胞。IV. 体内甲状腺激素水平的波动可调节幼鼠胸腺上皮细胞分泌胸腺素。
Thymic hormone containing cells. IV. Fluctuations in the thyroid hormone levels in vivo can modulate the secretion of thymulin by the epithelial cells of young mouse thymus.
作者信息
Savino W, Wolf B, Aratan-Spire S, Dardenne M
出版信息
Clin Exp Immunol. 1984 Mar;55(3):629-35.
Abstract
The influence of thyroid status on serum level and thymic content of thymulin, a thymic hormone, has been studied in young rats and mice treated by tri-iodothyronine (T3) or 6N-propyl-2-thiouracil (PTU). We showed that in vivo T3 administration induces in young animals an increase of their thymulin serum levels and of the number of thymulin containing cells in their thymuses. Conversely, a treatment with PTU decreases the thymulin serum levels and the number of cells containing the hormone. These findings suggest that thyroid hormones stimulate the synthesis and secretion of thymulin and represent further evidence for the hormonal influence on the regulation of thymic endocrine secretion.
摘要
在经三碘甲状腺原氨酸（T3）或6 - N - 丙基 - 2 - 硫氧嘧啶（PTU）处理的幼年大鼠和小鼠中，研究了甲状腺状态对胸腺激素胸腺素血清水平和胸腺含量的影响。我们发现，在幼年动物体内给予T3可使其胸腺素血清水平升高，胸腺中含胸腺素的细胞数量增加。相反，PTU处理则会降低胸腺素血清水平和含该激素的细胞数量。这些发现表明，甲状腺激素刺激胸腺素的合成和分泌，为激素对胸腺内分泌分泌调节的影响提供了进一步的证据。
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