儿童免疫球蛋白替代疗法
Immunoglobulin replacement therapy in children.
作者信息
Garcia-Lloret Maria, McGhee Sean, Chatila Talal A
机构信息
Division of Immunology, Allergy and Rheumatology, Department of Pediatrics, The David Geffen School of Medicine at the University of California at Los Angeles, MDCC 12-430, 10833 Le Conte Avenue, Los Angeles, CA 90095-1752, USA.
出版信息
Immunol Allergy Clin North Am. 2008 Nov;28(4):833-49, ix. doi: 10.1016/j.iac.2008.07.001.
Abstract
The benefit of immunoglobulin (IG) replacement in primary antibody deficiencies is unquestionable. Many of these congenital disorders present early in life and this therapy is often first implemented in the young. This article focuses on the indications of IG replacement in children, with an emphasis on the specific diagnostic problems encountered in this population. Also presented is an overview of the practical aspects of IG administration in the pediatric setting, including the recognition and management of adverse reactions. Finally, the advent of subcutaneous IG, a therapeutic IG modality with the potential to have a great impact on the quality of life of children with antibody deficiencies and their families, is discussed.
摘要
免疫球蛋白（IG）替代疗法在原发性抗体缺陷中的益处是毋庸置疑的。许多这类先天性疾病在生命早期就会出现，这种治疗方法通常首先应用于儿童。本文重点关注儿童IG替代疗法的适应证，着重探讨该人群中遇到的特殊诊断问题。还概述了儿科环境中IG给药的实际情况，包括不良反应的识别和处理。最后，讨论了皮下注射IG这一治疗性IG方式的出现，它有可能对抗体缺陷儿童及其家庭的生活质量产生重大影响。
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