Stepien Anna E, Arber Silvia
Biozentrum, Department of Cell Biology, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland.
Neuron. 2008 Oct 9;60(1):1-4. doi: 10.1016/j.neuron.2008.09.030.
The assembly of neuronal circuits involved in locomotor control in the mammalian spinal cord is influenced by genetic programs specifying four ventral (V) interneuron populations (V0-V3). In this issue of Neuron, Crone et al. and Zhang et al. make use of genetic tools to map connectivity patterns and to abolish the function of V2a and V3 interneurons. The absence of V2a interneurons reveals defects in left-right alternation during locomotion, whereas ablation of either V2a or V3 interneurons leads to disturbances in the precision and reliability of the motor output.
哺乳动物脊髓中参与运动控制的神经回路组装受指定四种腹侧（V）中间神经元群体（V0 - V3）的基因程序影响。在本期《神经元》杂志中，克朗等人和张等人利用基因工具绘制连接模式，并消除V2a和V3中间神经元的功能。V2a中间神经元缺失揭示了运动过程中左右交替的缺陷，而V2a或V3中间神经元的消融会导致运动输出的精度和可靠性受到干扰。
