So Emily Wing Sze, Ng Ernest Hung Yu, Wong Yu Yeuk, Lau Estella Yee Lan, Yeung William Shu Biu, Ho Pak Chung
Department of Obstetrics and Gynaecology, The University of Hong Kong, Hong Kong Special Administrative Region, Pokfulam Road, Hong Kong, People's Republic of China.
Hum Reprod. 2009 Feb;24(2):341-8. doi: 10.1093/humrep/den380. Epub 2008 Oct 21.
Acupuncture has been used during IVF treatment as it may improve outcome, however, there are concerns about the true efficacy of this approach. This randomized double blind study aimed to compare real acupuncture with placebo acupuncture in patients undergoing IVF treatment.
On the day of embryo transfer (ET), 370 patients were randomly allocated to either real or placebo acupuncture according to a computer-generated randomization list in sealed opaque envelopes. They received 25 min of real or placebo acupuncture before and after ET. The endometrial and subendometrial vascularity, serum cortisol concentration and the anxiety level were evaluated before and after real and placebo acupuncture.
The overall pregnancy rate was significantly higher in the placebo acupuncture group than that in the real acupuncture group (55.1 versus 43.8%, respectively, P = 0.038; Common odds ratio 1.578 95% confidence interval 1.047-2.378). No significant differences were found in rates of ongoing pregnancy and live birth between the two groups. Reduction of endometrial and subendometrial vascularity, serum cortisol concentration and the anxiety level were observed following both real and placebo acupuncture, although there were no significant differences in the changes in all these indices between the two groups.
Placebo acupuncture was associated with a significantly higher overall pregnancy rate when compared with real acupuncture. Placebo acupuncture may not be inert. Trial registered with HKClinicalTrials.com: number HKCTR-236.
针灸已被用于体外受精（IVF）治疗，因为它可能改善治疗结果，然而，人们对这种方法的真正疗效存在担忧。这项随机双盲研究旨在比较接受IVF治疗的患者接受真针灸与假针灸的效果。
在胚胎移植（ET）当天，根据计算机生成的随机列表，将370例患者随机分配到真针灸组或假针灸组，随机列表放在密封的不透明信封中。他们在ET前后接受25分钟的真针灸或假针灸。在真针灸和假针灸前后评估子宫内膜和子宫内膜下血管情况、血清皮质醇浓度和焦虑水平。
假针灸组的总体妊娠率显著高于真针灸组（分别为55.1%和43.8%，P = 0.038；共同优势比1.578，95%置信区间1.047 - 2.378）。两组之间的持续妊娠率和活产率没有显著差异。真针灸和假针灸后均观察到子宫内膜和子宫内膜下血管减少、血清皮质醇浓度和焦虑水平降低，尽管两组在所有这些指标的变化上没有显著差异。
与真针灸相比，假针灸的总体妊娠率显著更高。假针灸可能并非无效。在HKClinicalTrials.com注册的试验：编号HKCTR - 236。
