Diebold J, Temmim L, Bernadou A
Sem Hop. 1977 Jan 9;53(2):103-11.
In 349 subjects with Hodgkin's disease 520 bone marrow biopsies were carried out: 454 did not lead to the discovery of any tumour (87.5%), 66 permitted us to discover a tumour (12.5%). Among the bone marrows without Hodgkin tissue, the hematopoietic tissue was normal in 233 bone marrows (51.2%), hyperplastic in 157 bone marrows (34.7%), hypoplastic or aplastic in 64 bone marrows (14%). Eosinophilia was noted in 13% of cases, marked plasmacytosis was noted in 24%. Among the cases with a tumour, 89.2% showed a massive lesion; 10.7% showed partial lesions. The frequency of involvement was 5.4% for clinical stages I. 6.2% for stage II. 17.1% for stage III. 47.6% for stageIV. Bone marrow involvement at the start of the disease was found in 3% of cases, even in stages I and II. The involvements were especially frequent in the histological forms, stage III (19.4%) and IV (30.4%). In splenectomised patients, bone marrow involvement was 5 times more common when the spleen was also involved. 50 times more common when the liver was involved. The bone marrow which may be used to detect hematogenic spread of Hodgkin's disease is an investigation which should be carried out as a routine in the early stages of the disease and whenever a relapse is suspected.
对349例霍奇金病患者进行了520次骨髓活检：454次未发现任何肿瘤（87.5%），66次发现了肿瘤（12.5%）。在无霍奇金组织的骨髓中，造血组织正常的有233例（51.2%），增生的有157例（34.7%），发育不全或再生障碍的有64例（14%）。13%的病例有嗜酸性粒细胞增多，24%有明显的浆细胞增多。在有肿瘤的病例中，89.2%表现为大块病变；10.7%表现为部分病变。临床I期的受累频率为5.4%，II期为6.2%，III期为17.1%，IV期为47.6%。疾病开始时骨髓受累见于3%的病例，即使在I期和II期。在组织学类型中，III期（19.4%）和IV期（30.4%）的受累尤其常见。在脾切除的患者中，当脾脏也受累时，骨髓受累的情况是脾脏未受累时的5倍。当肝脏受累时，骨髓受累的情况是肝脏未受累时的50倍。可用于检测霍奇金病血行播散的骨髓检查应在疾病早期以及怀疑复发时作为常规检查进行。
