Minami K, Konno K, Honma M, Mizuno H, Fujimura S
Tohoku J Exp Med. 1976 Dec;120(4):329-37. doi: 10.1620/tjem.120.329.
In 1973 and 1974, an epidemic of acute hemorrhagic conjunctivitis (AHC) with a tendency of less frequent conjunctival hemorrhage occurred among the staff of the National Railways and their family in Sendai area. Four strains of AHC virus and 4 strains, 1 of type 7 and 3 of type 8, of adenoviruses were isolated from 22 conjunctival swabs of the patients. Thirty-six (66%) out of 55 cases examined were proved serologically to be of AHC virus infection, and 7 cases (13%) were of adenovirus infection. Clinically, infrequent association of hemorrhagic conjunctivitis was most remarkable. Only 10 cases (28%) had detectable signs of hemorrhagic conjunctivitis. There were no substantial changes in antigenicity and optimum temperature for virus multiplication between prototype and isolated strains. The isolated strains, however, seemed to be less neutralizable and less producible at 29 degrees C than prototype strain.
1973年和1974年，仙台地区国家铁路员工及其家属中发生了急性出血性结膜炎（AHC）疫情，结膜出血的频率较低。从患者的22份结膜拭子中分离出4株AHC病毒和4株腺病毒，其中1株为7型，3株为8型。在55例接受检查的病例中，36例（66%）血清学证实为AHC病毒感染，7例（13%）为腺病毒感染。临床上，出血性结膜炎的罕见关联最为显著。只有10例（28%）有可检测到的出血性结膜炎体征。原型株和分离株之间在抗原性和病毒增殖的最适温度方面没有实质性变化。然而，分离株在29摄氏度时似乎比原型株更不易被中和且产量更低。
