Mirkovic R R, Kono R, Yin-Murphy M, Sohier R, Schmidt N J, Melnick J L
Bull World Health Organ. 1973;49(4):341-6.
A new enterovirus, now classified as enterovirus type 70, was isolated from the conjunctiva of patients with acute haemorrhagic conjunctivitis during the 1971 epidemics that occurred in Japan, Singapore, and Morocco. These epidemics were parts of a pandemic involving Africa (Algeria, Ghana, Morocco, Nigeria, and Tunisia), Asia (Cambodia, China (Province of Taiwan), Hong Kong, India, Indonesia, Japan, Malaysia, the Philippines, Singapore, and Thailand), and England during 1969-71. A representative strain from each of the three epidemic areas was studied cooperatively. The strains exhibited the physicochemical characteristics of enteroviruses. Cross-neutralization tests showed that these viruses were distinct from all known human enterovirus immunotypes, but that they were antigenically closely related. The human origin of the viruses was demonstrated by the appearance of homologous neutralizing antibodies during convalescence in patients with acute haemorrhagic conjunctivitis.
1971年在日本、新加坡和摩洛哥发生急性出血性结膜炎疫情期间，从患者结膜中分离出一种新的肠道病毒，现归类为肠道病毒70型。这些疫情是1969 - 1971年涉及非洲（阿尔及利亚、加纳、摩洛哥、尼日利亚和突尼斯）、亚洲（柬埔寨、中国台湾省、香港、印度、印度尼西亚、日本、马来西亚、菲律宾、新加坡和泰国）以及英国的大流行的一部分。对来自三个疫区的代表性毒株进行了合作研究。这些毒株表现出肠道病毒的物理化学特性。交叉中和试验表明，这些病毒与所有已知的人类肠道病毒免疫型不同，但它们在抗原性上密切相关。急性出血性结膜炎患者康复期间出现同源中和抗体，证明了这些病毒的人类来源。
