D-环丝氨酸促进大鼠条件性觅酒行为的消退。
D-cycloserine facilitates extinction of conditioned alcohol-seeking behaviour in rats.
作者信息
Vengeliene Valentina, Kiefer Falk, Spanagel Rainer
机构信息
Department of Psychopharmacology, Central Institute of Mental Health (CIMH), University of Heidelberg, J5, 68159 Mannheim, Germany.
出版信息
Alcohol Alcohol. 2008 Nov-Dec;43(6):626-9. doi: 10.1093/alcalc/agn067.
AIMS
The aim of the present study was to examine the influence of partial NMDA receptor agonist d-cycloserine (DCS) on the extinction of conditioned alcohol-seeking behaviour.
METHODS
For this purpose, rats were administered with DCS 60 min before each successive extinction session. Resumption of alcohol responding was carried out 1 day after the final extinction session.
RESULTS
We demonstrate that treatment of rats with 5 mg/kg of DCS was capable in facilitating extinction of conditioned alcohol-seeking behaviour, which subsequently reduced the resumption of extinguished operant responding.
CONCLUSIONS
Our study suggests a good rationale for the development of new add-on medications for exposure-based psychotherapy so as to extinguish drug-conditioned appetitive memories in alcohol-dependent patients.
目的
本研究旨在探讨部分N-甲基-D-天冬氨酸（NMDA）受体激动剂d-环丝氨酸（DCS）对条件性觅酒行为消退的影响。
方法
为此，在每次连续消退训练前60分钟给大鼠注射DCS。在最后一次消退训练后1天进行酒精反应的恢复测试。
结果
我们证明，用5mg/kg的DCS处理大鼠能够促进条件性觅酒行为的消退，随后减少消退后操作性反应的恢复。
结论
我们的研究为开发新的辅助药物用于基于暴露的心理治疗提供了充分的理论依据，以便消除酒精依赖患者中药物条件性的奖赏记忆。
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