台湾儿童中淋巴毒素-α基因多态性与特应性哮喘的关联。

Association of a lymphotoxin-alpha gene polymorphism and atopic asthma in Taiwanese children.

作者信息

Huang Szu-Chao, Wu Wen-Jun, Sun Hai-Lun, Lue Ko-Huang, Hsu Chia-Hsiu, Liao Pei-Fen, Ku Min-Sho

机构信息

Division of Allergy, Asthma and Rheumatology, Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, Taiwan.

出版信息

Pediatr Neonatol. 2008 Apr;49(2):30-4. doi: 10.1016/S1875-9572(08)60008-X.

DOI:10.1016/S1875-9572(08)60008-X

PMID:18947013

Abstract

BACKGROUND

The lymphotoxin-alpha (LT-alpha) gene is located on chromosome 6 (6p21.1-6p21.3) and it may regulate tumor necrosis factor (TNF) production. TNF is a potent cytokine in the airway inflammatory response. Polymorphisms of TNF-associated genes have been related to asthma. This study investigated an LT-alpha-Ncol polymorphism in the first intron of the LT-alpha gene (LT-alpha-Ncol1 allele, as a variant type; and LT-alpha-Ncol2 allele), which may predispose individuals to asthma and atopy.

METHODS

Polymerase chain reaction-based assays were performed to determine LT-alpha-Ncol genotypes among our subjects. A genetic case control analysis was then performed on 114 atopic asthmatic and 155 non-asthmatic unrelated children.

RESULTS

There was a statistically higher frequency of LT-alpha-Ncol*1 allele carriers (1/1+1/2) in the subjects with atopic asthma than in controls (OR=1.923; 95% CI = 1.061-3.484; p = 0.031).

CONCLUSION

The results indicate that LT-alpha-Ncol*1 may be a risk factor for atopic asthma in Taiwanese children.

摘要

背景

淋巴毒素-α（LT-α）基因位于6号染色体（6p21.1 - 6p21.3）上，可能调控肿瘤坏死因子（TNF）的产生。TNF是气道炎症反应中的一种强效细胞因子。TNF相关基因的多态性与哮喘有关。本研究调查了LT-α基因第一个内含子中的LT-α - Ncol多态性（LT-α - Ncol1等位基因作为变异型；以及LT-α - Ncol2等位基因），其可能使个体易患哮喘和特应性疾病。