Department of Gastroenterology, The First People's Hospital of Chong Qing Liang Jiang New Area, Chongqing 401121, China.
J Healthc Eng. 2022 Mar 19;2022:9764770. doi: 10.1155/2022/9764770. eCollection 2022.
Cirrhosis is an active hepatic inflammation process of the liver considered as the serious phase of different liver injuries. Epidemiological studies have evaluated the possible association between TNF--308G/A gene polymorphism and liver cirrhosis. In this study, we have furthered the study to assess the exact association of TNF--308G/A gene polymorphism with liver cirrhosis susceptibility by integrating all available data. Eligible case-control studies were carried out from the establishment of the project to September 2021. Published literature from multiple databases was retrieved, collected, and analyzed by two investigators independently. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for every study. Review Manager 5.2 and Stata 15.0 software were used for meta-analysis and stability was assessed by both subgroup analysis and sensitivity analysis. Begg's funnel plot and Egger's regression across the studies were also explored. We examined 22 case-control studies with 2683 cirrhosis patients and 2905 normal controls in four genetic models (GA vs. GG: OR = 0.95, 95%CI: (0.70, 1.30); AA vs. GG: OR = 1.11, 95% CI: (0.66, 1.85), GA + AA vs. GG: OR = 1.00, 95% CI: (0.73, 1.37); AA vs. GA + GG: OR = 1.07, 95%CI: (0.70,1.63)). TNF--308G/A gene polymorphism was relatively independent, and the results did not show a significant difference between the two groups. In the subgroup analysis by etiological classification of liver cirrhosis, cirrhosis after HCV infection was positively associated with the risk of TNF--308G/A polymorphism (AA vs. GG: OR = 3.02, 95% CI: (1.15, 7.88), AA vs. GA + GG: OR = 2.68, 95% CI: (1.04, 6.95)). The meta-analysis showed TNF--308G/A gene polymorphism might not have affected susceptibility for liver cirrhosis. Nevertheless, further and well-designed studies were needed to confirm the findings.
肝硬化是一种活跃的肝脏炎症过程，被认为是不同肝脏损伤的严重阶段。流行病学研究已经评估了 TNF--308G/A 基因多态性与肝硬化之间可能存在的关联。在这项研究中，我们通过整合所有可用数据，进一步研究了 TNF--308G/A 基因多态性与肝硬化易感性的确切关联。从项目建立到 2021 年 9 月，进行了合格的病例对照研究。从多个数据库中检索、收集和分析已发表的文献，并由两名调查员独立进行。对每个研究计算了比值比（OR）和 95%置信区间（CI）。使用 Review Manager 5.2 和 Stata 15.0 软件进行荟萃分析，并通过亚组分析和敏感性分析评估稳定性。还探讨了贝叶斯漏斗图和研究间埃格的回归。我们检查了 22 项病例对照研究，包括 2683 名肝硬化患者和 2905 名正常对照者，在四个遗传模型中（GA 与 GG：OR=0.95，95%CI：（0.70，1.30）；AA 与 GG：OR=1.11，95%CI：（0.66，1.85），GA+AA 与 GG：OR=1.00，95%CI：（0.73，1.37）；AA 与 GA+GG：OR=1.07，95%CI：（0.70，1.63））。TNF--308G/A 基因多态性相对独立，两组之间的结果没有显著差异。根据肝硬化的病因学分类进行的亚组分析显示，HCV 感染后肝硬化与 TNF--308G/A 多态性的风险呈正相关（AA 与 GG：OR=3.02，95%CI：（1.15，7.88），AA 与 GA+GG：OR=2.68，95%CI：（1.04，6.95））。荟萃分析表明，TNF--308G/A 基因多态性可能不会影响肝硬化的易感性。然而，需要进一步进行设计良好的研究来证实这一发现。
