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中国人群哮喘易感基因的荟萃分析。

Asthma susceptible genes in Chinese population: a meta-analysis.

机构信息

Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China.

出版信息

Respir Res. 2010 Sep 24;11(1):129. doi: 10.1186/1465-9921-11-129.

DOI:10.1186/1465-9921-11-129
PMID:20868478
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2955661/
Abstract

BACKGROUND

Published data regarding the associations between genetic variants and asthma risk in Chinese population were inconclusive. The aim of this study was to investigate asthma susceptible genes in Chinese population.

METHODS

The authors conducted 18 meta-analyzes for 18 polymorphisms in 13 genes from eighty-two publications.

RESULTS

Seven polymorphisms were found being associated with risk of asthma, namely: A Disintegrin and Metalloprotease 33 (ADAM33) T1-C/T (odds ratio [OR] = 6.07, 95% confidence interval [CI]: 2.69-13.73), Angiotensin-Converting Enzyme (ACE) D/I (OR = 3.85, 95%CI: 2.49-5.94), High-affinity IgE receptor β chain (FcεRIβ) -6843G/A (OR = 1.49, 95%CI: 1.01-2.22), Interleukin 13(IL-13) -1923C/T (OR = 2.99, 95%CI: 2.12-4.24), IL-13 -2044A/G (OR = 1.49, 95%CI: 1.07-2.08), Regulated upon Activation, Normal T cell Expressed and Secreted (RANTES) -28C/G (OR = 1.64, 95%CI: 1.09-2.46), Tumor Necrosis Factor-α (TNF-α) -308G/A(OR = 1.42, 95%CI: 1.09, 1.85). After subgroup analysis by age, the ACE D/I, β2-Adrenergic Receptor (β2-AR) -79G/C, TNF-α -308G/A, Interleukin 4 receptor(IL-4R) -1902G/A and IL-13 -1923C/T polymorphisms were found significantly associated with asthma risk in Chinese children. In addition, the ACE D/I, FcεRIβ -6843G/A, TNF-α -308G/A, IL-13 -1923C/T and IL-13 -2044A/G polymorphisms were associated with asthma risk in Chinese adults.

CONCLUSION

ADAM33, FcεRIβ, RANTES, TNF-α, ACE, β2-AR, IL-4R and IL-13 genes could be proposed as asthma susceptible genes in Chinese population. Given the limited number of studies, more data are required to validate these associations.

摘要

背景

已发表的有关中国人群中遗传变异与哮喘风险之间关联的资料尚无定论。本研究旨在探讨中国人群中的哮喘易感基因。

方法

作者对 82 篇文献中的 13 个基因的 18 个多态性进行了 18 项荟萃分析。

结果

发现 7 种多态性与哮喘风险相关，即：A 分裂素和金属蛋白酶 33（ADAM33）T1-C/T（比值比[OR] = 6.07，95%置信区间[CI]：2.69-13.73），血管紧张素转换酶（ACE）D/I（OR = 3.85，95%CI：2.49-5.94），高亲和力 IgE 受体β链（FcεRIβ）-6843G/A（OR = 1.49，95%CI：1.01-2.22），白细胞介素 13（IL-13）-1923C/T（OR = 2.99，95%CI：2.12-4.24），IL-13-2044A/G（OR = 1.49，95%CI：1.07-2.08），调节激活正常 T 细胞表达和分泌（RANTES）-28C/G（OR = 1.64，95%CI：1.09-2.46），肿瘤坏死因子-α（TNF-α）-308G/A（OR = 1.42，95%CI：1.09,1.85）。按年龄进行亚组分析后，ACE D/I、β2-肾上腺素能受体（β2-AR）-79G/C、TNF-α-308G/A、白细胞介素 4 受体（IL-4R）-1902G/A 和白细胞介素 13-1923C/T 多态性与中国儿童哮喘风险显著相关。此外，ACE D/I、FcεRIβ-6843G/A、TNF-α-308G/A、IL-13-1923C/T 和 IL-13-2044A/G 多态性与中国成人哮喘风险相关。

结论

ADAM33、FcεRIβ、RANTES、TNF-α、ACE、β2-AR、IL-4R 和 IL-13 基因可被认为是中国人群中的哮喘易感基因。鉴于研究数量有限，需要更多的数据来验证这些关联。

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