Establishing the Irish Critical Care Trials Group: 'Who wins in battle makes many calculations before the battle is fought'.

Quality research, requiring large numbers of participants, in the intensive care unit (ICU) population requires multicentre collaboration. Although logistically challenging, this methodology reduces the influence of individual units and has greater validity and broader relevance to patients and practitioners. The nascent Irish Critical Care Trials Group opens additional such opportunities. In the accompanying epidemiologic study, the group present data gathered over 10 weeks of 2006 describing 1,029 patients, from 10 Irish ICUs representing over one-half of Ireland's critical care bed capacity. The data depict a busy service, with 78% of admissions being emergent and with a moderately high (7%) readmission rate. While recognising that there were missing data, the outcomes in organ failure and sepsis - where international definitions exist - and the ICU survival rate (83%) were consistent with international standards. The achievement of this planned first epidemiological step lays the foundation for the conduct of prospective scientific studies. These studies might occur in Ireland or in cooperation with other audit/scientific groups such as the UK's Intensive Care National Audit and Research Centre, the European Critical Care Research Network, or others. This brings us a small step closer to the prospect of global, high-volume studies in critical care.