Rogers Sally L, Viertlboeck Birgit C, Göbel Thomas W, Kaufman Jim
Terry Fox Laboratory, BC Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC V5Z 1L3, Canada.
Semin Immunol. 2008 Dec;20(6):353-60. doi: 10.1016/j.smim.2008.09.005. Epub 2008 Oct 22.
Natural killer (NK) activity has been examined in birds for over 30 years, but evidence that avian NK activity plays crucial roles in disease is only suggestive. In chickens, NK activity is mediated by TCR0 cells in the intestinal epithelium, but elsewhere subsets of alphabeta and gammadelta T cells (NKT cells) may be more important. There are few lectin-like NK receptor genes, located in the genomic region syntenic with the natural killer complex (NKC) as well as the major histocompatibility complex (MHC). In contrast, a huge number of Ig-like receptor genes are located in a region syntenic with the leukocyte receptor complex (LRC).
自然杀伤（NK）活性在鸟类中已被研究了30多年，但关于鸟类NK活性在疾病中起关键作用的证据仅具有启发性。在鸡中，NK活性由肠道上皮中的TCR0细胞介导，但在其他部位，αβ和γδ T细胞亚群（NKT细胞）可能更重要。几乎没有凝集素样NK受体基因，它们位于与自然杀伤复合体（NKC）以及主要组织相容性复合体（MHC）同线的基因组区域。相比之下，大量的免疫球蛋白样受体基因位于与白细胞受体复合体（LRC）同线的区域。
