Guo Pei, Cui Rui, Chang Yan-Zhong, Wu Wen-Shuang, Qian Zhong-Ming, Yoshida Kunihiro, Qiao Ya-Tiao, Takeda Shin'ichi, Duan Xiang-Lin
Laboratory of Molecular Iron Metabolism, College of Life Science, Hebei Normal University, Shijiazhuang 050016, Hebei Province, People's Republic of China.
Peptides. 2009 Feb;30(2):262-6. doi: 10.1016/j.peptides.2008.09.017. Epub 2008 Oct 2.
Hepcidin, a principle regulator of iron metabolism, is synthesized by the liver. Contradictory results have been reported on the regulation of hepcidin expression in response to serum transferrin saturation and liver iron content. In the present study, we explore the expression of murine hepcidin mRNA and further analyze the relationship between liver hepcidin mRNA expression, liver iron stores, and serum iron level utilizing ceruloplasmin gene knockout mice. We find that hepcidin expression correlates significantly with serum transferrin saturation, whereas there is a negative correlation of hepcidin expression with liver tissue iron level.
铁调素是铁代谢的主要调节因子，由肝脏合成。关于铁调素表达对血清转铁蛋白饱和度和肝脏铁含量的反应调节，已有相互矛盾的报道。在本研究中，我们利用铜蓝蛋白基因敲除小鼠探索小鼠铁调素mRNA的表达，并进一步分析肝脏铁调素mRNA表达、肝脏铁储存和血清铁水平之间的关系。我们发现铁调素表达与血清转铁蛋白饱和度显著相关，而铁调素表达与肝脏组织铁水平呈负相关。
