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[伪狂犬病病毒的几个特征]

[Several features of Aujeszky disease virus].

作者信息

Veselinova A, Motovski A

出版信息

Vet Med Nauki. 1976;13(7):9-15.

PMID:189486
Abstract

Clinical, virological, and morphological investigations were carried out on a total of 36 rabbits experimentally infected with five strains of the Aujeszky's disease virus. Those of the test animals that were infected with strain K did not die or died showing no clinical manifestations; those infected with strains K1. B, and TB showed nervous disturbances and died strongly scratching the site of injection. The animals infected with strain KB exhibited respiratory disturbances showing no death cases. Histopathologically, nonpurulent meningoencephalitis of the central nervous system was established in all animals. The rabbits infected with strain K (resistant to trypsin and temperature changes) and those infected with strain KB these lesions were more slightly expressed. The lungs of the affected animals showed interstitial intralobular phenomonia of a lympho-histiocytic type as a reactive necroses in the liver and spleen. In the case of K1, B, and TB infections no changes in the lungs and spleen were noticed, however, the liver was analogously affected. Results showed that those of those of the strains that were with lower virulence did not cause the clinical picture of scratching; such strains proved neurotropic and even strongly pheumotropic. It is concluded that the clinical and morphologic aspects observed in experimentally infected rabbits can be referred to in diagnosing the causative agent, differentiating strains that are slightly pathogenic from strains that are pathogenic.

摘要

对总共36只经五种奥耶斯基氏病病毒株实验感染的兔子进行了临床、病毒学和形态学研究。感染K株的试验动物未死亡或死亡时无临床表现;感染K1、B和TB株的动物出现神经紊乱,并在注射部位剧烈抓挠后死亡。感染KB株的动物出现呼吸紊乱,无死亡病例。组织病理学检查发现,所有动物均出现中枢神经系统非化脓性脑膜脑炎。感染K株(对胰蛋白酶和温度变化有抗性)和KB株的兔子,这些病变表现较轻。患病动物的肺部显示小叶内间质性淋巴细胞-组织细胞型肺炎,肝脏和脾脏出现反应性坏死。在感染K1、B和TB株的情况下,未观察到肺部和脾脏有变化,然而,肝脏受到类似影响。结果表明,毒力较低的毒株不会引起抓挠的临床表现;这些毒株被证明具有嗜神经性,甚至具有强烈的嗜肺性。得出的结论是,在实验感染兔子中观察到的临床和形态学方面可用于诊断病原体,区分致病性较弱的毒株和致病性毒株。

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