Sturniolo G C, Montino M C, Rossetto L, Martin A, D'Inca R, D'Odorico A, Naccarato R
Department of Internal Medicine, University of Padua, Italy.
J Am Coll Nutr. 1991 Aug;10(4):372-5. doi: 10.1080/07315724.1991.10718165.
Numerous factors seem to affect zinc absorption. Gastric acid secretion has been demonstrated to facilitate iron absorption. The zinc tolerance test (ZTT with ZnSO4 220 mg p.o.) was performed in 11 healthy volunteers to study the effects of administering the acid secretion inhibitor cimetidine (1 g/day p.o. for 3 days) and to evaluate the influence of HCl gastric secretion on zinc absorption in physiological conditions. Zinc absorption was reduced after cimetidine administration (p less than 0.005), suggesting that gastric pH influences zinc absorption. To rule out any direct effect of the drug on zinc absorption in five other healthy adults we further evaluated zinc absorption by using a different H2 antagonist (ranitidine 300 mg/day for 3 days and 300 mg before the test). Cimetidine was also tested in these subjects at half the dosage administered to the first group of subjects. Gastric acidity was monitored at 60-min intervals throughout the test via a nasogastric tube. The areas under the plasma concentration curves for zinc were significantly reduced after ranitidine (p less than 0.01), but not after cimetidine administration. Gastric acid was also reduced after ranitidine, but not after cimetidine (500 mg) administration, suggesting that gastric acid secretion plays a role in the regulation of zinc absorption in man.
许多因素似乎都会影响锌的吸收。胃酸分泌已被证明有助于铁的吸收。对11名健康志愿者进行了锌耐受试验（口服220毫克硫酸锌的ZTT），以研究给予胃酸分泌抑制剂西咪替丁（每天口服1克，共3天）的效果，并评估生理条件下盐酸胃分泌对锌吸收的影响。服用西咪替丁后锌吸收减少（p<0.005），表明胃pH值影响锌吸收。为排除药物对另外五名健康成年人锌吸收的任何直接影响，我们使用另一种H2拮抗剂（雷尼替丁，每天300毫克，共3天，试验前服用300毫克）进一步评估锌吸收。还对这些受试者以第一组受试者服用剂量的一半测试了西咪替丁。在整个试验过程中，通过鼻胃管每隔60分钟监测一次胃酸度。服用雷尼替丁后，锌的血浆浓度曲线下面积显著降低（p<0.01），但服用西咪替丁后没有降低。服用雷尼替丁后胃酸也降低了，但服用西咪替丁（500毫克）后没有降低，这表明胃酸分泌在人体锌吸收的调节中起作用。
