Kliemann Dimas Alexandre, Pasqualotto Alessandro Comarú, Falavigna Maicon, Giaretta Thiane, Severo Luiz Carlos
Programa de Pós-Graduação em Ciências Pneumológicas, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.
Rev Inst Med Trop Sao Paulo. 2008 Sep-Oct;50(5):261-3. doi: 10.1590/s0036-46652008000500002.
Although Candida albicans is the main cause of fungal esophagitis, other species such as C. tropicalis, C. krusei and C. stellatoidea have also been implicated. Several studies have identified risk factors for C. albicans esophagitis. However, data for non-C. albicans species is still sparse. The aim of this study was to determine the etiology of Candida esophagitis in our medical centre over an 18-month period. Additionally, we aimed to investigate predisposing conditions for esophageal candidosis caused by different Candida species. A total of 21,248 upper gastroscopies were performed in Santa Casa Complexo Hospitalar between January 2005 and July 2006. The prevalence of Candida esophagitis was 0.74% (n = 158). C. albicans caused the vast majority of infections (96.2%), followed by C. tropicalis (2.5%), C. lusitaniae (0.6%) and C. glabrata (0.6%). There were 81 women (51.3%) and 77 men (48.7%). No case of mixed infection occurred. Concomitant oral candidosis was documented for 10.8% (n = 17). Most of cases (55.1%) involved outpatients. Around one fifth of patients in our cohort had no identifiable risk factors for esophageal candidosis (20.8%). Since nearly all infections were caused by C. albicans we were not able to determine risk factors for esophagitis caused by other Candida species.
虽然白色念珠菌是真菌性食管炎的主要病因，但其他菌种如热带念珠菌、克柔念珠菌和星状念珠菌也有相关报道。多项研究已确定白色念珠菌食管炎的危险因素。然而，关于非白色念珠菌菌种的数据仍然稀少。本研究的目的是确定我们医疗中心18个月期间念珠菌性食管炎的病因。此外，我们旨在调查由不同念珠菌菌种引起的食管念珠菌病的易感因素。2005年1月至2006年7月期间，圣卡莎综合医院共进行了21248例上消化道内镜检查。念珠菌性食管炎的患病率为0.74%（n = 158）。白色念珠菌引起了绝大多数感染（96.2%），其次是热带念珠菌（2.5%）、葡萄牙念珠菌（0.6%）和光滑念珠菌（0.6%）。有81名女性（51.3%）和77名男性（48.7%）。未发生混合感染病例。记录有10.8%（n = 17）的患者伴有口腔念珠菌病。大多数病例（55.1%）为门诊患者。我们队列中约五分之一的患者没有可识别的食管念珠菌病危险因素（20.8%）。由于几乎所有感染都是由白色念珠菌引起的，我们无法确定其他念珠菌菌种引起的食管炎的危险因素。
