Paudyal Bishnuhari, Paudyal Pramila, Oriuchi Noboru, Tsushima Yoshito, Nakajima Takashi, Endo Keigo
Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, Japan.
Int J Oncol. 2008 Nov;33(5):1047-54.
Hepatocellular carcinoma (HCC) has variable 18F-fluoro-2-deoxy-D-glucose (18F-FDG) uptake and the relationship between 18F-FDG uptake with the expression of glucose transporters (Gluts) and hexokinase II (HK-II) has not been extensively examined. Present study explored the role of 18F-FDG positron emission tomography (PET) as a clinical significance and the association with Gluts and HK-II in patients with HCC. Whole body 18F-FDG PET, immunohistochemistry and western blot analysis of Glut-1 to Glut-5 and HK-II were performed in 31 patients (24 male and 7 female, range 48-75 years) with HCC. Significant correlation was found between 18F-FDG uptake and overall expression of Glut-2 (rho=0.55, p=0.002) and HK-II (rho=0.37, p=0.04). Expression of HK-II was correlated with Glut-2 (rho=0.57, p=0.0009) but not with other Gluts, which indicated that Glut-2 is a major glucose transporter. The prognosis of patients with SUV >/=2 and positive Glut-2 were significantly worse than that with SUV <2 and negative Glut-2 (p=0.005 and p=0.03), respectively. Multivariate analysis showed that SUV and lymph node metastasis were independent prognostic factors. The present study indicated that combined evaluation of 18F-FDG uptake and expression of Glut-2 might have an important role for management of patients with HCC.
肝细胞癌（HCC）的18F-氟-2-脱氧-D-葡萄糖（18F-FDG）摄取情况各异，18F-FDG摄取与葡萄糖转运蛋白（Gluts）及己糖激酶II（HK-II）表达之间的关系尚未得到广泛研究。本研究探讨了18F-FDG正电子发射断层扫描（PET）在HCC患者中的临床意义及其与Gluts和HK-II的关联。对31例（24例男性和7例女性，年龄范围48 - 75岁）HCC患者进行了全身18F-FDG PET检查、Glut-1至Glut-5及HK-II的免疫组织化学和蛋白质印迹分析。发现18F-FDG摄取与Glut-2的总体表达（rho = 0.55，p = 0.002）及HK-II的总体表达（rho = 0.37，p = 0.04）之间存在显著相关性。HK-II的表达与Glut-2相关（rho = 0.57，p = 0.0009），但与其他Gluts无关，这表明Glut-2是主要的葡萄糖转运蛋白。SUV≥2且Glut-2阳性的患者预后明显差于SUV<2且Glut-2阴性的患者（分别为p = 0.005和p = 0.03）。多变量分析显示SUV和淋巴结转移是独立的预后因素。本研究表明，联合评估18F-FDG摄取和Glut-2表达可能对HCC患者的管理具有重要作用。
