Paudyal Bishnuhari, Oriuchi Noboru, Paudyal Pramila, Tsushima Yoshito, Higuchi Tetsuya, Miyakubo Mitsuyuki, Ishikita Tomohiro, Nakajima Takashi, Endo Keigo
Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan.
Ann Nucl Med. 2008 Jan;22(1):83-6. doi: 10.1007/s12149-007-0076-1.
We report the results of (18)F-fluorodeoxyglucose positron emission tomography (FDG PET) and immunohistochemical staining of glucose transporter 1 (Glut-1) and hexokinase II (HK-II) in patients with hepatocellular carcinoma (HCC) and cholangiocellular carcinoma (CCC) to observe the variation in (18)F-FDG uptake and variation in expression of Glut-1 and HK-II in these hepatic tumors. In the case of HCC, moderate (18)F-FDG uptake and strong expression of HK-II were detected, whereas Glut-1 was not expressed. Conversely, CCC showed high (18)F-FDG uptake and increased expression of Glut-1 but HK-II was not expressed. The variation in the (18)F-FDG uptake and expression of Glut 1 and HK-II in HCC and CCC might be owing to the difference in origin and the different mechanisms involved in glucose uptake, rate of glucose transporters, and hexokinase activity involved in the glycolytic pathway.
我们报告了肝细胞癌（HCC）和胆管细胞癌（CCC）患者的（18）F-氟脱氧葡萄糖正电子发射断层扫描（FDG PET）结果，以及葡萄糖转运蛋白1（Glut-1）和己糖激酶II（HK-II）的免疫组织化学染色结果，以观察这些肝肿瘤中（18）F-FDG摄取的变化以及Glut-1和HK-II表达的变化。在HCC病例中，检测到中等程度的（18）F-FDG摄取和HK-II的强表达，而Glut-1未表达。相反，CCC显示出高（18）F-FDG摄取和Glut-1表达增加，但HK-II未表达。HCC和CCC中（18）F-FDG摄取以及Glut 1和HK-II表达的变化可能归因于起源的差异以及糖酵解途径中涉及的葡萄糖摄取、葡萄糖转运蛋白速率和己糖激酶活性的不同机制。
