BCL10核表达及t(11;18)(q21;q21)提示中国原发性胃黏膜相关淋巴组织淋巴瘤对幽门螺杆菌根除治疗无反应。
BCL10 nuclear expression and t(11;18)(q21;q21) indicate nonresponsiveness to Helicobacter pylori eradication of Chinese primary gastric MALT lymphoma.
作者信息
Dong Gehong, Liu Cuiling, Ye Hongtao, Gong Liping, Zheng Jie, Li Min, Huang Xin, Huang Xuebiao, Huang Yuanjie, Shi Yunfei, Yin Wenjuan, Gao Zifen
机构信息
Department of Pathology, Peking University Health Science Center, 100191, Beijing, People's Republic of China.
Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Cambridge, UK.
出版信息
Int J Hematol. 2008 Dec;88(5):516-523. doi: 10.1007/s12185-008-0187-z. Epub 2008 Oct 24.
The eradication of Helicobacter pylori (H. pylori) with antibiotics induces complete remission in 75% of patients with gastric MALT lymphoma. We investigated the efficacy of H. pylori eradication and assessed the predictive value of BCL10 nuclear expression and t(11;18)(q21;q21) regarding resistance to H. pylori eradication in primary gastric mucosa-associated lymphoid tissue lymphoma (MALT lymphoma) patients from mainland China. Twenty-two gastric MALT cases (Stage I(E)) underwent H. pylori eradication with antibiotics, and sequential endoscopic-bioptic follow-ups were performed and assessed with regular morphologic and immunohistochemical examinations. BCL10 nuclear expression and interphase fluorescence in situ hybridization (FISH) for MALT1 and API2/MALT1 were tested. Thirteen out of the 22 cases (59.1%) achieved complete regression (CR) after the eradication of H. pylori. The longest follow-up period in the 22 patients was 68 months, with 12 patients longer than 24 months. For the 13 CR patients, the longest follow-up period after H. pylori eradication was 53 months, with 6 patients longer than 24 months. BCL10 nuclear expression was detected by immunohistochemical staining in 9 cases, including 7 (77.8%) of 9 cases who showed no response (NR) and 2 (15.4%) of 13 patients who achieved CR following eradication therapy (P < 0.05). t(11;18)(q21;q21) was evaluated by interphase FISH in 18 cases including 11 CR and 7 NR patients after H. pylori eradication. t(11;18)(q21;q21) was found in 4 (57.1%) of 7 patients who showed NR following H. pylori eradication, but one in 11 CR patients (P < 0.05). A total of 59.1% of patients with early gastric MALT lymphoma recruited in this study achieved CR after H. pylori eradication. BCL10 nuclear expression and t(11;18)(q21;q21)-positive gastric MALT lymphomas are likely to be related to a failure to respond to H. pylori eradication in Chinese patients.
使用抗生素根除幽门螺杆菌（H. pylori）可使75%的胃黏膜相关淋巴组织淋巴瘤（MALT淋巴瘤）患者完全缓解。我们研究了中国大陆原发性胃黏膜相关淋巴组织淋巴瘤（MALT淋巴瘤）患者中幽门螺杆菌根除的疗效，并评估了BCL10核表达和t(11;18)(q21;q21)对幽门螺杆菌根除耐药性的预测价值。22例胃MALT淋巴瘤病例（I(E)期）接受了抗生素根除幽门螺杆菌治疗，并进行了序贯内镜活检随访，通过常规形态学和免疫组化检查进行评估。检测了BCL10核表达以及MALT1和API2/MALT1的间期荧光原位杂交（FISH）。22例患者中有13例（59.1%）在根除幽门螺杆菌后实现了完全缓解（CR）。22例患者的最长随访期为68个月，其中12例超过24个月。对于13例CR患者，根除幽门螺杆菌后的最长随访期为53个月，其中6例超过24个月。通过免疫组化染色检测到9例患者有BCL10核表达，其中9例中7例（77.8%）无反应（NR），而根除治疗后实现CR的13例患者中有2例（15.4%）有BCL10核表达（P<0.05）。18例患者通过间期FISH评估t(11;18)(q21;q21)，其中包括根除幽门螺杆菌后11例CR患者和7例NR患者。在根除幽门螺杆菌后显示NR的7例患者中有4例（57.1%）检测到t(11;18)(q21;q21)，而11例CR患者中有1例检测到（P<0.05）。本研究纳入的早期胃MALT淋巴瘤患者中，共有59.1%在根除幽门螺杆菌后实现了CR。BCL10核表达和t(11;18)(q21;q21)阳性的胃MALT淋巴瘤可能与中国患者对幽门螺杆菌根除治疗无反应有关。
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