Hiraki Susan, Chen Clara A, Roberts J Scott, Cupples L Adrienne, Green Robert C
Dept of Neurology, Boston University School of Medicine, Boston, MA, USA.
J Genet Couns. 2009 Apr;18(2):130-6. doi: 10.1007/s10897-008-9194-8. Epub 2008 Oct 23.
Perceived risk is a complex concept that influences the genetic counseling process and can affect client coping and behavior. Although the association between family history and risk perception is well recognized in the literature, no studies have explored this relationship specifically in those seeking genetic susceptibility testing for a common chronic condition. REVEAL is a randomized trial assessing the impact of APOE disclosure and genetic risk assessment for Alzheimer's disease (AD). Using baseline REVEAL data, we hypothesized that there would be a significant association between the degree of AD family history and risk perception of AD, and that this relationship would be stronger in those who believed that genetics is a very important AD risk factor. In our sample of 293 participants, we found that a higher self-perceived risk of AD was associated with strength of family history of AD (p < 0.001), belief in genetics as an important AD risk factor (p < 0.001), being female (p < 0.001) and being Caucasian (p = 0.02). These results are the first to demonstrate the association between family history and risk perception in persons volunteering for genetic susceptibility testing for a common complex disease.
感知风险是一个复杂的概念，它会影响遗传咨询过程，并可能影响客户的应对方式和行为。尽管家族史与风险感知之间的关联在文献中已得到充分认可，但尚无研究专门探讨那些因常见慢性病寻求遗传易感性检测的人群中的这种关系。REVEAL是一项随机试验，评估载脂蛋白E（APOE）信息披露和阿尔茨海默病（AD）遗传风险评估的影响。利用REVEAL的基线数据，我们假设AD家族史的程度与AD的风险感知之间存在显著关联，并且这种关系在那些认为遗传学是AD非常重要的风险因素的人群中会更强。在我们293名参与者的样本中，我们发现较高的自我感知AD风险与AD家族史的强度相关（p < 0.001）、认为遗传学是重要AD风险因素（p < 0.001）、女性（p < 0.001）和白种人（p = 0.02）。这些结果首次证明了在为常见复杂疾病进行遗传易感性检测的志愿者中家族史与风险感知之间的关联。
