CDC-Uganda, Global AIDS Program, National Center for HIV, Viral Hepatitis, STD and TB Prevention, Uganda Virus Research Institute, Centers for Disease Control and Prevention (CDC), Entebbe, Uganda.
AIDS Behav. 2010 Aug;14(4):816-23. doi: 10.1007/s10461-008-9481-2. Epub 2008 Oct 24.
This paper examines HIV risk behavior among HIV-uninfected adults living with people taking antiretroviral therapy (ART) in Uganda. A prospective cohort of 455 HIV-uninfected non-spousal household members of ART patients receiving home-based AIDS care was enrolled. Sexual behavior, HIV risk perceptions, AIDS-related anxiety, and the perception that AIDS is curable were assessed at baseline, 6, 12 and 24 months. Generalized linear mixture models were used to model risk behavior over time and to identify behavioral correlates. Overall, risky sex decreased from 29% at baseline to 15% at 24-months. Among women, risky sex decreased from 31% at baseline to 10% at 6 months and 15% at 24 months. Among men, risky sex decreased from 30% at baseline to 8% at 6 months and 13% at 24 months. Perceiving HIV/AIDS as curable and lower AIDS-related anxiety were independently associated with risky sex. No evidence of behavioral disinhibition was observed. Concerns regarding behavioral disinhibition should not slow down efforts to increase ART access in Africa.
本研究旨在探讨乌干达未感染 HIV 的成年人与接受抗逆转录病毒治疗（ART）的患者共同生活时的 HIV 风险行为。研究纳入了 455 名未感染 HIV 的非配偶 ART 患者家庭护理员。在基线、6、12 和 24 个月时评估性行为、HIV 风险认知、艾滋病相关焦虑和艾滋病可治愈性的感知。使用广义线性混合模型来模拟随时间变化的风险行为，并确定行为相关性。总体而言，高危性行为从基线时的 29%下降到 24 个月时的 15%。在女性中，高危性行为从基线时的 31%下降到 6 个月时的 10%和 24 个月时的 15%。在男性中，高危性行为从基线时的 30%下降到 6 个月时的 8%和 24 个月时的 13%。认为 HIV/AIDS 可治愈和艾滋病相关焦虑程度较低与高危性行为独立相关。未观察到行为抑制的证据。不应因为担心行为抑制而减缓在非洲增加 ART 获得的努力。
