Eisele Thomas P, Mathews Catherine, Chopra Mickey, Brown Lisanne, Silvestre Eva, Daries Vanessa, Kendall Carl
Department of International Health and Development, Tulane University School of Public Health and Tropical Medicine, 1440 Canal Street, Suite 2200, New Orleans, LA 70112, USA.
AIDS Behav. 2008 Jul;12(4):570-7. doi: 10.1007/s10461-007-9279-7. Epub 2007 Jul 17.
Baseline data were collected in Cape Town during 2006 to study if patients on combination antiretroviral therapy (ART) experience decreased inhibition to avoid risky sexual behavior. A total of 924 HIV-positive individuals were recruited; 520 who initiated ART within 3 months and 404 waiting for ART. Nearly half of men (40.1%) and women (46.3%) reported having unprotected sex their last time. Men and women who did not disclose their HIV status to their partner [Odds ration (OR)=2.57 (95% CI: 1.22-5.50) and 2.84 (95% CI: 1.84-4.39), respectively], and those with ambivalent perception about the relationship between ART and HIV transmission [OR=2.08 (95% CI: 1.00-4.30) and 2.39 (95% CI: 1.50-3.84), respectively], were twice as likely to have had unprotected sex their last time. Results suggest an urgent need to strengthen prevention interventions among HIV-positive individuals on and about to start ART in this setting.
2006年在开普敦收集了基线数据，以研究接受联合抗逆转录病毒疗法（ART）的患者是否会减少对避免危险行为的抑制。总共招募了924名艾滋病毒呈阳性的个体；其中520人在3个月内开始接受ART治疗，404人等待接受ART治疗。近一半的男性（40.1%）和女性（46.3%）报告称他们上一次发生了无保护性行为。未向伴侣透露自己艾滋病毒感染状况的男性和女性[优势比（OR）分别为2.57（95%置信区间：1.22 - 5.50）和2.84（95%置信区间：1.84 - 4.39）]，以及对ART与艾滋病毒传播之间关系认识模糊的男性和女性[OR分别为2.08（95%置信区间：1.00 - 4.30）和2.39（95%置信区间：1.50 - 3.84）]，上一次发生无保护性行为的可能性是其他人的两倍。结果表明，迫切需要加强对在这种情况下正在接受或即将开始接受ART治疗的艾滋病毒呈阳性个体的预防干预措施。
