Ohishi A, Yanai K, Saioth T, Kanno R, Kogure M, Takeshige T, Teranishi Y, Usuba A, Inoue H, Motoki R
First Department of Surgery, Fukushima Medical College, Japan.
Nihon Kyobu Geka Gakkai Zasshi. 1991 Jun;39(6):855-61.
After lobectomy, it is recognized that functional as well as absolute reduction occurs in residual lobes of the operated side. So whether lobectomy is indicated or not is determined by the same criteria as those for pneumonectomy, namely, by the unilateral pulmonary artery occlusion (UPAO) test. However, is it really appropriate to use the same criteria for both lobectomy and pneumonectomy? To answer to this question, in patients with lung cancer we compared the hemodynamics after lobectomy (13 cases) and pneumonectomy (14 cases) with that at the UPAO test. After pneumonectomy, the mean pulmonary arterial wedge pressure (mPWP) was significantly lower than that on the preoperative day and at the test. It seemed that hypovolemic change occurred in the hemodynamics after pneumonectomy. After pneumonectomy, the pulmonary arteriolar resistance index (PARI) was significantly higher than the preoperative value. It was the same as that as at the time of the UPAO test. The total pulmonary vascular resistance index (TPVRI) at the time of the test was significantly higher than the preoperative value, but the TPVRI after pneumonectomy was not significantly higher. The TPVRI tended to decrease after pneumonectomy, compared to the value predicated by the test. These results indicated that some of the cases judged inoperable on the basis of the UPAO test might be operable. On the day of lobectomy, the PARI was significantly higher than the preoperative value, but significantly lower than that at the time of the test. The cardiac index (CI) was significantly higher and the mPWP was significantly lower than each preoperative value.(ABSTRACT TRUNCATED AT 250 WORDS)
肺叶切除术后,人们认识到手术侧残留肺叶会出现功能以及绝对体积的减小。因此,肺叶切除术是否适用与全肺切除术的判断标准相同,即通过单侧肺动脉闭塞(UPAO)试验来确定。然而,将相同的标准用于肺叶切除术和全肺切除术真的合适吗?为了回答这个问题,我们在肺癌患者中比较了肺叶切除术(13例)和全肺切除术(14例)后的血流动力学与UPAO试验时的血流动力学。全肺切除术后,平均肺动脉楔压(mPWP)显著低于术前及试验时的值。全肺切除术后的血流动力学似乎出现了血容量减少的变化。全肺切除术后,肺小动脉阻力指数(PARI)显著高于术前值,与UPAO试验时相同。试验时的总肺血管阻力指数(TPVRI)显著高于术前值,但全肺切除术后的TPVRI没有显著升高。与试验预测值相比,全肺切除术后TPVRI有下降趋势。这些结果表明,一些基于UPAO试验判断为不可手术的病例可能是可手术的。在肺叶切除当天,PARI显著高于术前值,但显著低于试验时的值。心脏指数(CI)显著高于术前值,mPWP显著低于术前值。(摘要截选至250词)