Jung Young-Chul, Park Hae-Jeong, Kim Jae-Jin, Chun Ji Won, Kim Hye Sun, Kim Nam Wook, Son Sang Jun, Oh Maeng-Gun, Lee Jong Doo
Department of Psychiatry, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemeun-gu, Seoul 120-752, Republic of Korea.
Brain Res. 2008 Dec 30;1246:136-43. doi: 10.1016/j.brainres.2008.09.081. Epub 2008 Oct 11.
The neural basis of ambivalence has not yet been identified. We investigated the prefrontal cortical activations implicated in evaluative processing of ambivalent stimuli under the forced and non-forced response conditions. Cerebral blood flow was measured using H(2)(15)O positron emission tomography in twelve normal volunteers during a modified word-stem completion task that was designed to evoke different conditions of ambivalence. The prefrontal cortical activations were restricted to the orbitofrontal cortex during the non-forced ambivalent condition, whereas the ventrolateral prefrontal cortex and the frontopolar cortex were activated in addition to the orbitofrontal cortex during the forced ambivalent condition. It is remarkable that the orbitofrontal cortex and the ventrolateral prefrontal cortex demonstrated a reciprocal activation pattern, which might be linked to the evaluative attitude toward the ambivalent stimuli.
矛盾情绪的神经基础尚未明确。我们研究了在强制和非强制反应条件下，与矛盾刺激的评估处理相关的前额叶皮质激活情况。在一项旨在引发不同矛盾情绪条件的改良词干补全任务中，使用H(2)(15)O正电子发射断层扫描技术测量了12名正常志愿者的脑血流量。在非强制矛盾条件下，前额叶皮质激活局限于眶额皮质，而在强制矛盾条件下，除眶额皮质外，腹外侧前额叶皮质和额极皮质也被激活。值得注意的是，眶额皮质和腹外侧前额叶皮质呈现出相互激活模式，这可能与对矛盾刺激的评估态度有关。
