Frey Stephen, Kostopoulos Penelope, Petrides Michael
Montreal Neurological Institute, Montreal, Quebec, Canada H3A 2B4.
Neuroimage. 2004 Jul;22(3):1384-9. doi: 10.1016/j.neuroimage.2004.03.018.
Having recently demonstrated that the human orbitofrontal cortex is selectively activated during the encoding of visual information, we investigated whether this same frontal region, which is directly connected to medial temporal structures, would be activated during the encoding of auditory stimuli. We measured cerebral blood flow (CBF) with positron emission tomography (PET) during the encoding of nonverbal abstract auditory stimuli in a group of young healthy volunteers. The results demonstrate that the left orbitofrontal cortex, area 11 in particular, is involved in the encoding of auditory information. We suggest that the orbitofrontal cortex is a critical frontal region that can exert top-down regulation of other regions of the brain including the medial temporal structures and the lateral frontal cortex, enabling the further processing of information.
最近我们证实，人类眶额皮质在视觉信息编码过程中被选择性激活。我们进而研究，这个与内侧颞叶结构直接相连的额叶区域，在听觉刺激编码过程中是否也会被激活。我们对一组年轻健康志愿者进行正电子发射断层扫描（PET），测量其在非语言抽象听觉刺激编码过程中的脑血流量（CBF）。结果表明，左侧眶额皮质，尤其是11区，参与了听觉信息的编码。我们认为，眶额皮质是一个关键的额叶区域，能够对包括内侧颞叶结构和外侧额叶皮质在内的大脑其他区域进行自上而下的调节，从而使信息得到进一步处理。
