Stein Amelie, Panjkovich Alejandro, Aloy Patrick
Institute for Research in Biomedicine, Barcelona Supercomputing Center, c/ Baldiri Reixac 10-12, 08028 Barcelona, Spain.
Nucleic Acids Res. 2009 Jan;37(Database issue):D300-4. doi: 10.1093/nar/gkn690. Epub 2008 Oct 25.
The database of 3D interacting domains (3did) is a collection of protein interactions for which high-resolution 3D structures are known. 3did exploits structural information to provide the crucial molecular details necessary for understanding how protein interactions occur. Besides interactions between globular domains, the new release of 3did also contains a hand-curated set of transient peptide-mediated interactions. The interactions are grouped in Interaction Types, based on the mode of binding, and the different binding interfaces used in each type are also identified and catalogued. A web-based tool to query 3did is available at http://3did.irbbarcelona.org.
3D相互作用结构域数据库（3did）是一个已知高分辨率3D结构的蛋白质相互作用集合。3did利用结构信息来提供理解蛋白质相互作用如何发生所需的关键分子细节。除了球状结构域之间的相互作用外，3did的新版本还包含一组人工挑选的瞬时肽介导的相互作用。这些相互作用根据结合模式分组为相互作用类型，并且还识别和编目了每种类型中使用的不同结合界面。可通过http://3did.irbbarcelona.org访问基于网络的3did查询工具。
