Ouppatham S, Bancha S, Choovichian P
Division of Nephrology, Department of Medicine, Phramongkutklao Hospital and College of Medicine, Bangkok, Thailand.
J Postgrad Med. 2008 Oct-Dec;54(4):259-62. doi: 10.4103/0022-3859.43509.
Previous studies have demonstrated a strong association of hypertension and renal disease with gout. Nevertheless, controversy remains concerning serum uric acid concentration as an independent factor of hypertension.
To explore the relationship between systolic blood pressure (SBP) and diastolic blood pressure (DBP) with serum uric acid levels.
An observational study.
A total of 5,564 subjects from the Armed Forces Research Institute of Medical Sciences were included in the study.
ANOVA tests, Chi-square test, correlation coefficients, and multiple regression analysis were performed.
Of the total subjects, 4,099 (73.7%) were male. Mean SBP and DBP were 128.73+/-17.06 and 81.62 +/- 11.58 mm Hg, respectively. The mean serum uric acid level was 6.54 +/- 1.71 mg/dL. A significant and positive correlation was found both between serum uric acid and SBP (r=0.186, P P CONCLUSIONS: In this study, we suggest that serum uric acid be used to correlate with levels of blood pressure in the general population. Further investigation is required to establish the treatment for hyperuricemia in hypertensive patients.
既往研究已证实高血压和肾脏疾病与痛风之间存在密切关联。然而，血清尿酸浓度作为高血压的一个独立因素仍存在争议。
探讨收缩压（SBP）和舒张压（DBP）与血清尿酸水平之间的关系。
一项观察性研究。
本研究纳入了来自武装部队医学科学研究所的5564名受试者。
进行方差分析、卡方检验、相关系数分析和多元回归分析。
在所有受试者中，4099名（73.7%）为男性。平均收缩压和舒张压分别为128.73±17.06和81.62±11.58毫米汞柱。平均血清尿酸水平为6.54±1.71毫克/分升。血清尿酸与收缩压之间存在显著正相关（r = 0.186，P < 0.001），血清尿酸与舒张压之间也存在显著正相关（r = 0.169，P < 0.001）。多元回归分析显示，血清尿酸是收缩压和舒张压的独立预测因子。
在本研究中，我们建议将血清尿酸用于与一般人群的血压水平进行关联分析。需要进一步研究以确定高血压患者高尿酸血症的治疗方法。
