1] Division of Regenerative Medicine and Therapeutics, Institute of Regenerative Medicine and Biofunction, Tottori University Graduate School of Medical Sciences, Yonago, Japan [2] Department of Cardiology, Toranomon Hospital, Tokyo, Japan [3] Department of Cardiology, St Luke's International Hospital, Tokyo, Japan.
Department of Cardiology, St Luke's International Hospital, Tokyo, Japan.
Hypertens Res. 2014 Aug;37(8):785-9. doi: 10.1038/hr.2014.75. Epub 2014 Mar 27.
The cause and effect relationship between serum uric acid levels and hypertension can be difficult to evaluate because antihypertensive drugs sometimes affect uric acid levels. This cross-sectional study investigated the relationship between serum uric acid levels and hypertension in a general, healthy Japanese population who were not receiving medication for hyperuricemia or hypertension. We retrospectively analyzed the medical records of 90 143 Japanese people (men, 49.1%; age, 46.3±12.0 years) undergoing an annual medical examination at St Luke's International Hospital Center for Preventive Medicine, Tokyo, between January 2004 and June 2010. Of these individuals, 82 722 (91.8%) who had never taken medications for gout, hyperuricemia or hypertension were enrolled. We compared the participant characteristics and prevalence of diastolic hypertension (⩾90 mm Hg) and/or systolic hypertension (⩾140 mm Hg) by serum uric acid quartile. The odds ratio (OR) of hypertension was 1.20 for each 1 mg dl(-1) increase in serum uric acid level after adjustment for age, sex, body mass index (BMI), dyslipidemia, diabetes, smoking and estimated glomerular filtration rate (eGFR). Compared with the lowest serum uric acid quartile, participants in the highest quartile had a 3.7-fold higher OR for hypertension. After adjustment for age, BMI, dyslipidemia, diabetes, smoking and eGFR, these ORs were 1.79 (1.62-1.98) in the total study population, 1.58 (1.44-1.75) in men and 1.60 (1.39-1.84) in women. The results were similar for both systolic and diastolic hypertension. Elevated serum uric acid levels may be as important as obesity, dyslipidemia, diabetes, smoking and reduced kidney function for the development of hypertension and should be considered in hypertension prevention programs.
血清尿酸水平与高血压之间的因果关系很难评估，因为降压药物有时会影响尿酸水平。本横断面研究调查了在未接受高尿酸血症或高血压药物治疗的一般健康的日本人群中，血清尿酸水平与高血压之间的关系。我们回顾性分析了 2004 年 1 月至 2010 年 6 月期间在东京圣卢克国际医院预防医学中心接受年度体检的 90143 名日本人（男性，49.1%；年龄，46.3±12.0 岁）的病历。其中，有 82722 人（91.8%）从未服用过治疗痛风、高尿酸血症或高血压的药物。我们比较了血清尿酸四分位组参与者的特征和舒张期高血压（≥90mmHg）和/或收缩期高血压（≥140mmHg）的患病率。在校正年龄、性别、体重指数（BMI）、血脂异常、糖尿病、吸烟和估计肾小球滤过率（eGFR）后，血清尿酸水平每增加 1mg/dl（-1），高血压的比值比（OR）为 1.20。与最低血清尿酸四分位组相比，最高四分位组的高血压 OR 为 3.7 倍。在校正年龄、BMI、血脂异常、糖尿病、吸烟和 eGFR 后，在整个研究人群中，这些 OR 分别为 1.79（1.62-1.98）、男性为 1.58（1.44-1.75）和女性为 1.60（1.39-1.84）。这些结果与收缩期和舒张期高血压均相似。血清尿酸水平升高与肥胖、血脂异常、糖尿病、吸烟和肾功能下降一样，可能对高血压的发生发展至关重要，应在高血压预防计划中加以考虑。
