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慢性血液透析的尿毒症患者的多发性神经病(临床形态学发现)

[Polyneuropathy in uremic patients in chronic hemodialysis (clinico-morphologic findings].

作者信息

Potomskaia L Z, Stroumova I V

出版信息

Zh Nevropatol Psikhiatr Im S S Korsakova. 1976;76(11):1610-6.

PMID:189535
Abstract

Among 50 patients who suffered from chronic renal insufficiency and who were on a chronic hemodialysis, 25 demonstrated uremic polyneuropathy with a different degree of expressiveness which depended upon the duration azotemia. A histological study of 13 postmortem cases detected a microfocal demyelinization in the peripheral nerves, and in cases of expressed pathology there were changes in the axon cast of the peripheral nerves and neurogenic muscular atrophy. There were no direct correlations between the development of polyneuropathy and the amount of hemodialysis sessions.

摘要

在50例患有慢性肾功能不全且正在进行慢性血液透析的患者中,25例表现出不同程度的尿毒症性多发性神经病,其程度取决于氮质血症的持续时间。对13例尸检病例的组织学研究发现,周围神经存在微灶性脱髓鞘,在病变明显的病例中,周围神经轴突管和神经源性肌肉萎缩有变化。多发性神经病的发生与血液透析次数之间没有直接关联。

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