Jacobsen Marc, Mattow Jens, Repsilber Dirk, Kaufmann Stefan H E
Max Planck Institute for Infection Biology, Department of Immunology, D-10117 Berlin, Germany.
Biol Chem. 2008 May;389(5):487-95. doi: 10.1515/bc.2008.053.
The more we learn about the immune response against tuberculosis (TB) and particularly about the features which distinguish protective immunity, disease susceptibility and pathology, the better we can define biomarkers which correlate with these different stages of infection. The most widely used biomarker in TB, which without a doubt is an important component of protective immunity, is IFNgamma secreted by antigen-specific CD4 T-cells. However, the complexity of the immune response against TB makes it more than likely that additional biomarkers are required for a reliable correlate of protection. As a corollary, we assume that a set of biomarkers will be required, termed a biosignature.
我们对结核病（TB）免疫反应了解得越多，尤其是对区分保护性免疫、疾病易感性和病理学的特征了解得越多，就越能更好地定义与感染不同阶段相关的生物标志物。结核病中使用最广泛的生物标志物是抗原特异性CD4 T细胞分泌的IFNγ，毫无疑问，它是保护性免疫的重要组成部分。然而，针对结核病的免疫反应的复杂性使得很可能还需要其他生物标志物才能可靠地关联保护作用。因此，我们假设需要一组生物标志物，称为生物特征。
