微小RNA是结核病免疫的合适生物标志物吗？
Are microRNAs suitable biomarkers of immunity to tuberculosis?
作者信息
Ueberberg Bianca, Kohns Malte, Mayatepek Ertan, Jacobsen Marc
机构信息
Department of General Pediatrics, Neonatology, and Pediatric Cardiology, University Children's Hospital, Moorenstr. 5, 40225, Duesseldorf, Germany.
出版信息
Mol Cell Pediatr. 2014 Dec;1(1):8. doi: 10.1186/s40348-014-0008-9. Epub 2014 Oct 3.
Abstract
BACKGROUND
MicroRNAs (miRNAs) are crucial regulators of human immunity e.g. against Mycobacterium tuberculosis. Against the background of still alarming high mortality of tuberculosis effective biomarkers to improve diagnosis of M. tuberculosis infection and successful treatment are of major importance.
CONCLUSIONS
This review summarizes recent surrogate tissue studies for identification of miRNA biomarker candidates in human tuberculosis with a special focus on reproducibility and conformance. In addition we provide assistance for the design of biomarker studies to circumvent major pitfalls.
摘要
背景
微小RNA（miRNA）是人类免疫（如针对结核分枝杆菌的免疫）的关键调节因子。在结核病死亡率仍然高得惊人的背景下，有效的生物标志物对于改善结核分枝杆菌感染的诊断和成功治疗至关重要。
结论
本综述总结了近期用于鉴定人类结核病中miRNA生物标志物候选物的替代组织研究，特别关注可重复性和一致性。此外，我们为生物标志物研究的设计提供帮助，以避免主要陷阱。
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