Diastereoselective palladium-catalyzed alpha-arylation of 4-substituted cyclohexyl esters.
作者信息
Bercot Eric A, Caille Seb, Bostick Tracy M, Ranganathan Krishnakumar, Jensen Randy, Faul Margaret M
机构信息
Chemical Process R&D, Amgen Inc, Thousand Oaks, California 91320, USA.
出版信息
Org Lett. 2008 Nov 20;10(22):5251-4. doi: 10.1021/ol8021758. Epub 2008 Oct 28.
PMID:18954065
Abstract
A diastereoselective palladium-catalyzed arylation of 4-substituted cyclohexyl esters has been developed. The reaction proceeds at room temperature in the presence of [(t-Bu3P)PdBr]2 providing products in up to 37:1 dr.
摘要
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