Paduano L, Giglio L, Bembi B, Peratoner L, Benussi G
Department of Pediatric Surgery, Istituto per l'Infanzia, Burlo Garofolo, Trieste, Italy.
J Urol. 1991 Oct;146(4):1097-8. doi: 10.1016/s0022-5347(17)38010-2.
Among 8,579 neonates born between February 1, 1981 and March 31, 1987, and cleared by prenatal sonography for significant urinary tract abnormality 158 subsequently were hospitalized because of signs or symptoms of urinary tract disease, predominantly urinary tract infection. Evaluation of these 158 patients revealed 24 with vesicoureteral reflux, 7 with duplicated systems (2 of which showed reflux), 1 with the syndrome of Fraley, 1 with pyelectasis and 5 with mild hydronephrosis (3 secondary to reflux and 2 with diethylenetriaminepentaacetic acid renal scans considered to be nonobstructed). There was no incidence of significant obstructive uropathy that had been missed by the previous prenatal sonography and that surfaced subsequently to cause morbidity in this series. The principal disorder of the urinary tract that may fail prenatal investigation is vesicoureteral reflux.
在1981年2月1日至1987年3月31日出生的8579例新生儿中，经产前超声检查排除明显泌尿系统异常的新生儿，有158例随后因泌尿系统疾病的体征或症状住院，主要是尿路感染。对这158例患者的评估显示，24例有膀胱输尿管反流，7例有重复肾系统（其中2例显示反流），1例有弗雷利综合征，1例有肾盂扩张，5例有轻度肾积水（3例继发于反流，2例经二乙烯三胺五乙酸肾扫描认为无梗阻）。在本系列中，没有出现先前产前超声检查遗漏、随后出现并导致发病的严重梗阻性尿路病。产前检查可能遗漏的主要泌尿系统疾病是膀胱输尿管反流。
