Hirata N, Sakakibara T, Watanabe S, Nomura F, Akamatsu H, Matsumura Y, Yamamoto K, Sasaki J, Kodama K
Division of Cardiovascular Surgery, Osaka Police Hospital, Japan.
Jpn Circ J. 1991 Aug;55(8):745-52. doi: 10.1253/jcj.55.745.
The effects of congenital right ventricular pressure and volume overload were studied in 3 patients with pulmonary stenosis, 7 with atrial septal defect and 6 with atrial septal defect plus pulmonary stenosis late after successful surgical correction. Gated equilibrium blood pool radionuclide ventriculography was used to measure right ventricular function at rest and during exercise and to compare it with eight normal subjects. Right ventricular ejection fractions at rest and during exercise were measured to be 61 +/- 9% and 66 +/- 13%, respectively, in the group with pulmonary stenosis, 49 +/- 7% and 54 +/- 8% in the group with atrial septal defect, and 65 +/- 13% and 69 +/- 13% in the group with atrial septal defect plus pulmonary stenosis. The values in the groups with pulmonary stenosis and atrial septal defect plus pulmonary stenosis were significantly higher than the control subjects (45 +/- 5% and 51 +/- 5%, p less than 0.01). The peak filling rate at rest and during exercise was also significantly higher in the groups with pulmonary stenosis and atrial septal defect plus pulmonary stenosis than in controls (at rest, 2.72 +/- 0.72, 2.53 +/- 0.94 vs. 1.64 +/- 0.24 p less than 0.05; during exercise, 4.38 +/- 1.23, 4.13 +/- 1.18 vs. 2.52 +/- 0.62, p less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
研究了3例肺动脉狭窄、7例房间隔缺损以及6例房间隔缺损合并肺动脉狭窄且已成功接受手术矫正的患者，观察先天性右心室压力和容量超负荷的影响。采用门控平衡血池放射性核素心室造影术测量静息和运动时的右心室功能，并与8名正常受试者进行比较。结果显示，肺动脉狭窄组静息和运动时的右心室射血分数分别为61±9%和66±13%；房间隔缺损组分别为49±7%和54±8%；房间隔缺损合并肺动脉狭窄组分别为65±13%和69±13%。肺动脉狭窄组和房间隔缺损合并肺动脉狭窄组的数值显著高于对照组（45±5%和51±5%，p<0.01）。肺动脉狭窄组和房间隔缺损合并肺动脉狭窄组静息和运动时的峰值充盈率也显著高于对照组（静息时，2.72±0.72、2.53±0.94 对比1.64±0.24，p<0.05；运动时，4.38±1.23、4.13±1.18对比2.52±0.62，p<0.01）。（摘要截断于250字）
