Buckman Sam G, Hodgson Stephen R, Hofford Rebecca S, Eitan Shoshana
Behavioral and Cellular Neuroscience, Department of Psychology, Texas A&M University, College Station, TX 77843 United States.
Behav Brain Res. 2009 Feb 11;197(2):454-6. doi: 10.1016/j.bbr.2008.09.035. Epub 2008 Oct 8.
Rats undergoing both naloxone-precipitated and spontaneous opioid withdrawal exhibit anxiogenic behaviors in the elevated plus maze (EPM). Recently, we observed an unexpected result, namely mice exhibited increased EPM open-arm time during naloxone-precipitated morphine withdrawal. This was surprising since this behavioral outcome is usually associated with an anxiolytic profile. This study demonstrates that mice exhibit an increase in both EPM open-arm time and % open-arm entries also during spontaneous opioid withdrawal.
经历纳洛酮诱发的和自发的阿片类药物戒断的大鼠在高架十字迷宫（EPM）中表现出焦虑行为。最近，我们观察到一个意外的结果，即在纳洛酮诱发的吗啡戒断期间，小鼠在EPM开放臂上的停留时间增加。这很令人惊讶，因为这种行为结果通常与抗焦虑特征相关。本研究表明，在自发阿片类药物戒断期间，小鼠在EPM开放臂上的停留时间和进入开放臂的百分比也会增加。
