Kumita S, Nishimura T, Uehara T, Shimonagata T
Department of Radiology, National Cardiovascular Center, Osaka.
Kaku Igaku. 1991 Jun;28(6):591-7.
A quantitative index of left ventricular wall motion obtained from ECG-gated planar myocardial images has been developed. Five normal controls and 39 patients with heart disease received an injection of Tc-99m-MIBI (550-740 MBq) at rest, and ECG-gated planar scintigraphy (LAO view) was performed 3 h later. Mean End-diastolic (ED) and end-systolic (ES) myocardial activities were measured using circumferential profile analysis and %count increase (CI) was determined according to the following formula; (ES count-ED count)/(ED count) x 100. The global %CI was compared with the EF obtained from contrast ventriculography (LVG; n = 29) and radionuclide ventriculography using Tc-99m-labelled RBC (RNV; n = 24). The regional %CI was compared with left ventricular wall motion assessed by LVG. The global %CI was correlated well with EF by LVG (r = 0.70) and EF by RNV (r = 0.75). The regional %CI significantly decreased in accordance with wall motion on LVG worsened at impaired region. In conclusion, gated perfusion imaging with Tc-99m-MIBI provides useful information on ventricular function in addition to myocardial perfusion.
已开发出一种从心电图门控平面心肌图像中获取的左心室壁运动定量指标。5名正常对照者和39名心脏病患者在静息状态下注射99mTc-MIBI（550 - 740 MBq），3小时后进行心电图门控平面闪烁显像（左前斜位）。使用圆周轮廓分析法测量舒张末期（ED）和收缩末期（ES）心肌平均活性，并根据以下公式确定计数增加百分比（CI）：(ES计数 - ED计数)/(ED计数)×100。将整体CI百分比与经对比心室造影（LVG；n = 29）和使用99mTc标记红细胞的放射性核素心室造影（RNV；n = 24）获得的射血分数（EF）进行比较。将局部CI百分比与通过LVG评估的左心室壁运动进行比较。整体CI百分比与LVG测得的EF（r = 0.70）和RNV测得的EF（r = 0.75）相关性良好。在受损区域，局部CI百分比随着LVG上壁运动恶化而显著降低。总之，99mTc-MIBI门控灌注显像除了提供心肌灌注信息外，还能提供有关心室功能的有用信息。
