Sodowski K, Zwirska-Korczala K, Kuka D, Kukla M, Budziszewska P, Zebaty A, Wender-Ozegowska E, Baumert M, Wloch A
Obstetrics and Gynecology Clinic, Ruda Slaska, Medical University of Silesia, Katowice, Poland.
J Physiol Pharmacol. 2008 Sep;59 Suppl 4:33-43.
Among the proteins secreted by adipocytes, acylation stimulating protein (ASP), which plays a crucial role in energetic balance regulation, merits particular attention. ASP is a protein of the C3 complement system, responsible for glucose and lipids metabolism in an insulin-independent mechanism. ASP's role during pregnancy and its interactions with pregnancy hormones remains unknown. The lipogenic character of ASP may impose a question as to what extent this hormone participates in pregnant women lipogenesis, and what is the basal and postprandial ASP secretion during the second trimester of pregnancy. The results of the examinations of 26 pregnant women during the second trimester of their first pregnancy were analyzed. Due to the limited data available in the literature, a control group was examined. The group consisted of 8 healthy non-pregnant patients within similar age ranges. Blood samples were collected in order to determine ASP, total cholesterol, HDL, LDL and triglyceride levels. Basal ASP levels present in obese pregnant women (group OBP; 30.20 +/- 2.13 ng/mL) were significantly higher than those in the healthy control group (group LnP; 20.49 +/- 1.97 ng/mL), P<0.05. Mann-Whitney U test- analysis of these group differences indicated that OBP patients had significantly higher ASP levels than controls at 30 (P<0.01), 60 (P<0.01), and 120 (P<0.01) min after a meal. After a meal, the incremental ASP area under the curve in group OBW patients was significantly higher from that observed in control group LnP (718,9 +/- 263,9 ng/mL x 2h vs. 35,1 +/- 14,6 ng/mL x 2h, P<0.05). Basal concentration of triglycerides, total cholesterol and LDL cholesterol were significantly higher in all pregnant women compared to the group of non-obese non-pregnant women. It was found that lipid parameters were highly dependent upon body mass gain during pregnancy. Group OBP demonstrated significantly higher basal concentrations of all parameters of lipid metabolism in comparison with the remaining groups of pregnant patients. In conclusion, we found abnormalities of ASP and lipid profiles in lean, overweight, and obese pregnant women strictly connected with obesity. Acylation stimulating protein correlated with lipid parameters, suggesting increased risk of dyslipidemia in obese pregnant women.
在脂肪细胞分泌的蛋白质中，酰化刺激蛋白（ASP）在能量平衡调节中起着关键作用，值得特别关注。ASP是C3补体系统的一种蛋白质，以胰岛素非依赖机制负责葡萄糖和脂质代谢。ASP在孕期的作用及其与妊娠激素的相互作用尚不清楚。ASP的生脂特性可能引发一个问题，即这种激素在多大程度上参与孕妇的脂肪生成，以及妊娠中期基础和餐后ASP的分泌情况如何。分析了26名初孕孕妇妊娠中期的检查结果。由于文献中可用数据有限，设立了一个对照组。该组由8名年龄范围相似的健康非孕患者组成。采集血样以测定ASP、总胆固醇、高密度脂蛋白、低密度脂蛋白和甘油三酯水平。肥胖孕妇组（OBP组；30.20±2.13 ng/mL）的基础ASP水平显著高于健康对照组（LnP组；20.49±1.97 ng/mL），P<0.05。对这些组间差异进行曼-惠特尼U检验分析表明，餐后30分钟（P<0.01）、60分钟（P<0.01）和120分钟（P<0.01）时，OBP组患者的ASP水平显著高于对照组。餐后，OBW组患者曲线下ASP增量面积显著高于对照组LnP（718.9±263.9 ng/mL×2小时对35.1±14.6 ng/mL×2小时，P<0.05）。与非肥胖非孕女性组相比，所有孕妇的甘油三酯、总胆固醇和低密度脂蛋白胆固醇基础浓度均显著更高。研究发现脂质参数高度依赖于孕期体重增加。与其余孕妇组相比，OBP组脂质代谢所有参数的基础浓度均显著更高。总之，我们发现体重正常妊娠、超重和肥胖孕妇中ASP和脂质谱异常与肥胖密切相关。酰化刺激蛋白与脂质参数相关，提示肥胖孕妇血脂异常风险增加。
