Ohta H, Ni X H, Matsumoto K, Watanabe H
Section of Pharmacology, Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Japan.
Jpn J Pharmacol. 1991 Jul;56(3):303-9. doi: 10.1254/jjp.56.303.
Young (5 month) and aged (23 month) male rats were tested in delayed nonmatching to position task using a T-maze, and their ability of working memory retention was assessed over interrun intervals ranging between 5 and 300 sec. There were no significant age differences in pretest performance at 0 sec interval, but significant memory loss was observed in aged rats when tested with the interrun intervals. Physostigmine (0.1 and 0.2 mg/kg) improved this age-related decline in working memory in a dose-dependent manner, whereas the treatment slightly but not significantly improved the performance of young rats. These results suggest that the central cholinergic system in aged rats was functionally deteriorated and that stimulation of the system could enhance working memory retention in aged rats.
使用T型迷宫对年轻（5个月）和老年（23个月）雄性大鼠进行位置延迟非匹配任务测试，并在5至300秒的不同组间间隔评估它们的工作记忆保持能力。在0秒间隔的预测试表现上，年龄差异不显著，但在不同组间间隔测试时，老年大鼠出现了显著的记忆丧失。毒扁豆碱（0.1和0.2毫克/千克）以剂量依赖的方式改善了这种与年龄相关的工作记忆衰退，而该处理对年轻大鼠的表现有轻微但不显著的改善。这些结果表明，老年大鼠的中枢胆碱能系统功能退化，刺激该系统可增强老年大鼠的工作记忆保持能力。
