Parsons D S, Peagler A, Barlow T S, Harrell L E
Exp Neurol. 1987 May;96(2):456-61. doi: 10.1016/0014-4886(87)90062-8.
To assess the potential usefulness of chronic acetylcholinesterase inhibition in the treatment of learning/memory disorders arising from central cholinergic deficient states, physostigmine was administered chronically to rats with medial septal lesions and the retention of a spatial/working memory task investigated. Three dose levels of physostigmine (0.025, 0.05, 0.075 mg/kg) were administered three times per day following medial septal lesions. Retention of a standard radial 8-arm maze task was assessed. Although the lesions transiently disrupted task performance, physostigmine therapy did not improve either daily performance or total recovery time. Our results suggest that chronic acetylcholinesterase inhibition is not effective in ameliorating the working memory deficits that occur after medial septal lesions.
为评估慢性乙酰胆碱酯酶抑制在治疗中枢胆碱能缺乏状态引起的学习/记忆障碍中的潜在效用，对患有内侧隔损伤的大鼠长期给予毒扁豆碱，并研究其对空间/工作记忆任务的保持情况。内侧隔损伤后，每天三次给予三种剂量水平的毒扁豆碱（0.025、0.05、0.075毫克/千克）。评估标准放射状八臂迷宫任务的保持情况。尽管损伤暂时扰乱了任务表现，但毒扁豆碱治疗并未改善每日表现或总恢复时间。我们的结果表明，慢性乙酰胆碱酯酶抑制在改善内侧隔损伤后出现的工作记忆缺陷方面无效。
