Choi Gi Young, Yang Hyeon Woong, Cho Soung Hoon, Kang Dong Wook, Go Hoon, Lee Woong Chul, Lee Yun Jung, Jung Sung Hee, Kim An Na, Cha Sang Woo
Department of Internal Medicine, Eulji University School of Medicine, Eulji University Hospital, Daejeon, Korea.
J Korean Med Sci. 2008 Oct;23(5):903-5. doi: 10.3346/jkms.2008.23.5.903.
Albendazole binds to parasite's tubulin inhibiting its glucose absorption. Its common adverse effects are nausea, vomiting, constipation, thirst, dizziness, headache, hair loss and pruritus. Although mainly metabolized in the liver, abnormal liver function tests were a rare adverse effect during clinical trials and we found no literature about albendazole-induced hepatitis requiring admission. This patient had a previous history of albendazole ingestion in 2002 resulting in increase of liver function tests. And in 2005, the episode repeated. We evaluated the patient for viral hepatitis, alcoholic liver disease, and autoimmune hepatitis, but no other cause of hepatic injury could be found. Liver biopsy showed periportal steatosis and periportal necrosis. The initial abnormal liver function test improved only with supportive care. These findings and the Roussel Uclaf Causality Assessment Method of the Council for International Organizations of Medical Sciences (RUCAM/CIOMS) score of 9 are compatible with drug-induced hepatitis so we report the case of this patient with a review of the literature.
阿苯达唑与寄生虫的微管蛋白结合，抑制其葡萄糖吸收。其常见不良反应有恶心、呕吐、便秘、口渴、头晕、头痛、脱发和瘙痒。虽然主要在肝脏代谢，但在临床试验期间肝功能检查异常是一种罕见的不良反应，而且我们未发现有关需要住院治疗的阿苯达唑诱发肝炎的文献。该患者曾在2002年服用过阿苯达唑，导致肝功能检查结果升高。2005年，同样的情况再次出现。我们对该患者进行了病毒性肝炎、酒精性肝病和自身免疫性肝炎的评估，但未发现其他肝损伤原因。肝活检显示门周脂肪变性和门周坏死。最初的肝功能检查异常仅通过支持治疗得到改善。这些发现以及国际医学科学组织理事会的罗塞尔·优克福因果关系评估方法（RUCAM/CIOMS）评分为9分，与药物性肝炎相符，因此我们报告该患者病例并对文献进行综述。
