阿苯达唑诱发复发性急性中毒性肝炎：一例报告

Albendazole Induced Recurrent Acute Toxic Hepatitis: A Case Report.

作者信息

Bilgic Yilmaz, Yilmaz Cengiz, Cagin Yasir Furkan, Atayan Yahya, Karadag Nese, Harputluoglu Murat Muhsin Muhip

机构信息

Inonu University, Turgut Ozal Medical Center, Department of Gastroenterology, Malatya, Turkey.

Inonu University, Turgut Ozal Medical Center, Department of Pathology, Malatya, Turkey.

出版信息

Acta Gastroenterol Belg. 2017 Apr-Jun;80(2):309-311.

PMID:29560698

Abstract

INTRODUCTION

Drug induced acute toxic hepatitis can be idiosyncratic. Albendazole, a widely used broad spectrum antiparasitic drug is generally accepted as a safe drug. It may cause asymptomatic transient liver enzyme abnormalities but acute toxic hepatitis is very rare. Case Report : Herein, we present the case of 47 year old woman with recurrent acute toxic hepatitis after a single intake of albendazole in 2010 and 2014. The patient was presented with symptoms and findings of anorexia, vomiting and jaundice. For diagnosis, other acute hepatitis etiologies were excluded. Roussel Uclaf Causality Assessment Method (RUCAM) score was calculated and found to be 10, which meant highly probable drug hepatotoxicity. Within 2 months, all pathological findings came to normal.

RESULT

There are a few reported cases of albendazole induced toxic hepatitis, but at adults, there is no known recurrent acute toxic hepatitis due to albendazole at this certainty according to RUCAM score.

CONCLUSION

Physicians should be aware of this rare and potentially fatal adverse effect of albendazole.

摘要

引言

药物性急性中毒性肝炎可能是特异质性的。阿苯达唑是一种广泛使用的广谱抗寄生虫药物，通常被认为是一种安全的药物。它可能会引起无症状的短暂性肝酶异常，但急性中毒性肝炎非常罕见。病例报告：在此，我们报告一例47岁女性病例，该患者在2010年和2014年单次服用阿苯达唑后反复出现急性中毒性肝炎。患者出现厌食、呕吐和黄疸的症状及体征。为明确诊断，排除了其他急性肝炎病因。计算了鲁塞尔·乌克拉夫因果关系评估法（RUCAM）评分，结果为10分，这意味着药物性肝毒性高度可能。在2个月内，所有病理结果恢复正常。