涎腺切除对大鼠辣椒素敏感的“胃防御机制”的影响。

Influence of sialoadenectomy on capsaicin-sensitive "gastric defense mechanism" in rats.

作者信息

Evangelista S, Maggi C A

机构信息

Pharmacology Department, Menarini Pharmaceuticals, Firenze, Italy.

出版信息

Jpn J Pharmacol. 1991 Jul;56(3):377-80. doi: 10.1254/jjp.56.377.

DOI:10.1254/jjp.56.377

PMID:1895582

Abstract

Chemical ablation of sensory afferents produced by the treatment with the neurotoxin capsaicin worsened gastric ulcers induced by 50% ethanol in sham- and sialoadenectomized (SALX)-operated rats. Conversely, capsaicin worsened water immersion stress (WIS)-ulcers in SALX, but not those in sham-operated animals. The concomitant removal of two potent antisecretory factors, such as salivary gland containing epidermal growth factor and neuropeptides contained in the sensory afferents, is probably responsible for the enhanced vulnerability of the mucosa in WIS-ulcers.

摘要

用神经毒素辣椒素处理导致的感觉传入神经化学消融，使假手术和唾液腺切除（SALX）手术的大鼠因50%乙醇诱导的胃溃疡恶化。相反，辣椒素使SALX大鼠的水浸应激（WIS）溃疡恶化，但对假手术动物的WIS溃疡无此作用。同时去除两种有效的抗分泌因子，如含有表皮生长因子的唾液腺和感觉传入神经中含有的神经肽，可能是导致WIS溃疡中黏膜易损性增加的原因。